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Title: Quantifying interictal metabolic activity in human temporal lobe epilepsy

Abstract

The majority of patients with complex partial seizures of unilateral temporal lobe origin have interictal temporal hypometabolism on (18F)fluorodeoxyglucose positron emission tomography (FDG PET) studies. Often, this hypometabolism extends to ipsilateral extratemporal sites. The use of accurately quantified metabolic data has been limited by the absence of an equally reliable method of anatomical analysis of PET images. We developed a standardized method for visual placement of anatomically configured regions of interest on FDG PET studies, which is particularly adapted to the widespread, asymmetric, and often severe interictal metabolic alterations of temporal lobe epilepsy. This method was applied by a single investigator, who was blind to the identity of subjects, to 10 normal control and 25 interictal temporal lobe epilepsy studies. All subjects had normal brain anatomical volumes on structural neuroimaging studies. The results demonstrate ipsilateral thalamic and temporal lobe involvement in the interictal hypometabolism of unilateral temporal lobe epilepsy. Ipsilateral frontal, parietal, and basal ganglial metabolism is also reduced, although not as markedly as is temporal and thalamic metabolism.

Authors:
; ; ; ; ; ;  [1]
  1. (Univ. of California, Los Angeles (USA))
Publication Date:
OSTI Identifier:
6792716
Alternate Identifier(s):
OSTI ID: 6792716
Resource Type:
Journal Article
Journal Name:
Journal of Cerebral Blood Flow and Metabolism; (USA)
Additional Journal Information:
Journal Volume: 10:5; Journal ID: ISSN 0271-678X
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; BRAIN; POSITRON COMPUTED TOMOGRAPHY; EPILEPSY; DIAGNOSIS; GLUCOSE; METABOLISM; FLUORINE 18; PATIENTS; ALDEHYDES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBOHYDRATES; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HEXOSES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; MONOSACCHARIDES; NERVOUS SYSTEM; NERVOUS SYSTEM DISEASES; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIOISOTOPES; SACCHARIDES; TOMOGRAPHY 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics; 550901 -- Pathology-- Tracer Techniques

Citation Formats

Henry, T.R., Mazziotta, J.C., Engel, J. Jr., Christenson, P.D., Zhang, J.X., Phelps, M.E., and Kuhl, D.E. Quantifying interictal metabolic activity in human temporal lobe epilepsy. United States: N. p., 1990. Web. doi:10.1038/jcbfm.1990.128.
Henry, T.R., Mazziotta, J.C., Engel, J. Jr., Christenson, P.D., Zhang, J.X., Phelps, M.E., & Kuhl, D.E. Quantifying interictal metabolic activity in human temporal lobe epilepsy. United States. doi:10.1038/jcbfm.1990.128.
Henry, T.R., Mazziotta, J.C., Engel, J. Jr., Christenson, P.D., Zhang, J.X., Phelps, M.E., and Kuhl, D.E. Sat . "Quantifying interictal metabolic activity in human temporal lobe epilepsy". United States. doi:10.1038/jcbfm.1990.128.
@article{osti_6792716,
title = {Quantifying interictal metabolic activity in human temporal lobe epilepsy},
author = {Henry, T.R. and Mazziotta, J.C. and Engel, J. Jr. and Christenson, P.D. and Zhang, J.X. and Phelps, M.E. and Kuhl, D.E.},
abstractNote = {The majority of patients with complex partial seizures of unilateral temporal lobe origin have interictal temporal hypometabolism on (18F)fluorodeoxyglucose positron emission tomography (FDG PET) studies. Often, this hypometabolism extends to ipsilateral extratemporal sites. The use of accurately quantified metabolic data has been limited by the absence of an equally reliable method of anatomical analysis of PET images. We developed a standardized method for visual placement of anatomically configured regions of interest on FDG PET studies, which is particularly adapted to the widespread, asymmetric, and often severe interictal metabolic alterations of temporal lobe epilepsy. This method was applied by a single investigator, who was blind to the identity of subjects, to 10 normal control and 25 interictal temporal lobe epilepsy studies. All subjects had normal brain anatomical volumes on structural neuroimaging studies. The results demonstrate ipsilateral thalamic and temporal lobe involvement in the interictal hypometabolism of unilateral temporal lobe epilepsy. Ipsilateral frontal, parietal, and basal ganglial metabolism is also reduced, although not as markedly as is temporal and thalamic metabolism.},
doi = {10.1038/jcbfm.1990.128},
journal = {Journal of Cerebral Blood Flow and Metabolism; (USA)},
issn = {0271-678X},
number = ,
volume = 10:5,
place = {United States},
year = {1990},
month = {9}
}