Use of PET for estimation of radiation dose variations within the thyroid from radioiodine therapy in thyrotoxic patients

Ott, R J; Batty, V; Clack, R; Flower, M A; Leach, M O; Marsden, P; McCready, V R; Webb, S

Title: Use of PET for estimation of radiation dose variations within the thyroid from radioiodine therapy in thyrotoxic patients

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Abstract

A series of 22 patients have been studied using a prototype Multiwire Proportional Chamber Positron Camera to determine the accuracy of measurement of thyroid uptake of radioiodine. The patients being treated for thyrotoxicosis were given a solution containing 1.5 mCi of I-131 and 0.7 mCi of I-124. In a few case 0.3 mCi of I-124 was given prior to I-131 therapy. Data acquisition consisted of 8 contiguous views of the thyroid covering the full 360 degrees around the patient. Each study contained approximately 400,000 events. Data analysis consisted of a simple backprojection and 3D deconvolution of the point source response function to produce a 64x64x64 volume matrix using 0.27ml voxels. The volume of the thyroid was obtained using a simple thresholding technique to determine the number of voxels within the thyroid. Phantom measurements show that the functional volume and hence the radiation dose to the thyroid can be estimated to approx. =10%. From conventional imaging with a gamma camera plus pinhole collimator, 18 out of 22 patients were diagnosed as having uniform Graves disease. The high resolution tomographic information provided by PET imaging has shown that the uptake in 5 of these 18 patients was multinodular. In one case themore »« less

Authors:: Ott, R J; Batty, V; Clack, R; Flower, M A; Leach, M O; Marsden, P; McCready, V R; Webb, S

Publication Date:: Wed May 01 00:00:00 EDT 1985

Research Org.:: Royal Marsden Hospital, Sutton, Surrey

OSTI Identifier:: 6791771

Report Number(s):: CONF-850611-
Journal ID: CODEN: JNMEA; TRN: 87-011060

Resource Type:: Conference

Journal Name:: J. Nucl. Med.; (United States)

Additional Journal Information:: Journal Volume: 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; POSITRON COMPUTED TOMOGRAPHY; CAMERAS; MULTIWIRE PROPORTIONAL CHAMBERS; RADIOPHARMACEUTICALS; UPTAKE; THYROID; DATA ACQUISITION; DIAGNOSIS; HYPERTHYROIDISM; IODINE ISOTOPES; MONITORING; PATIENTS; RADIATION DOSES; RADIOTHERAPY; TISSUE DISTRIBUTION; BODY; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DISTRIBUTION; DOSES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; ENDOCRINE DISEASES; ENDOCRINE GLANDS; GLANDS; ISOTOPES; LABELLED COMPOUNDS; MEASURING INSTRUMENTS; MEDICINE; NUCLEAR MEDICINE; ORGANS; PROPORTIONAL COUNTERS; RADIATION DETECTORS; RADIOLOGY; THERAPY; TOMOGRAPHY; 550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-); 550601 - Medicine- Unsealed Radionuclides in Diagnostics; 550501 - Metabolism- Tracer Techniques

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                    Ott, R J, Batty, V, Clack, R, Flower, M A, Leach, M O, Marsden, P, McCready, V R, and Webb, S. Use of PET for estimation of radiation dose variations within the thyroid from radioiodine therapy in thyrotoxic patients.  United States: N. p., 1985. 
        Web.

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                    Ott, R J, Batty, V, Clack, R, Flower, M A, Leach, M O, Marsden, P, McCready, V R, & Webb, S. Use of PET for estimation of radiation dose variations within the thyroid from radioiodine therapy in thyrotoxic patients.  United States.

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                    Ott, R J, Batty, V, Clack, R, Flower, M A, Leach, M O, Marsden, P, McCready, V R, and Webb, S. 1985.  
        "Use of PET for estimation of radiation dose variations within the thyroid from radioiodine therapy in thyrotoxic patients".  United States.

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@article{osti_6791771,

  title        = {Use of PET for estimation of radiation dose variations within the thyroid from radioiodine therapy in thyrotoxic patients},

  author       = {Ott, R J and Batty, V and Clack, R and Flower, M A and Leach, M O and Marsden, P and McCready, V R and Webb, S},

  abstractNote = {A series of 22 patients have been studied using a prototype Multiwire Proportional Chamber Positron Camera to determine the accuracy of measurement of thyroid uptake of radioiodine. The patients being treated for thyrotoxicosis were given a solution containing 1.5 mCi of I-131 and 0.7 mCi of I-124. In a few case 0.3 mCi of I-124 was given prior to I-131 therapy. Data acquisition consisted of 8 contiguous views of the thyroid covering the full 360 degrees around the patient. Each study contained approximately 400,000 events. Data analysis consisted of a simple backprojection and 3D deconvolution of the point source response function to produce a 64x64x64 volume matrix using 0.27ml voxels. The volume of the thyroid was obtained using a simple thresholding technique to determine the number of voxels within the thyroid. Phantom measurements show that the functional volume and hence the radiation dose to the thyroid can be estimated to approx. =10%. From conventional imaging with a gamma camera plus pinhole collimator, 18 out of 22 patients were diagnosed as having uniform Graves disease. The high resolution tomographic information provided by PET imaging has shown that the uptake in 5 of these 18 patients was multinodular. In one case the volume of the nodules within the thyroid was estimated to be 45% of the organ volume. This non-uniform uptake of iodine within the thyroid has consequences for the overall management of hyperthyroidism in patients thought to have Graves disease. It may in part explain the cases of unexpected post therapy hypothyroidism.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/6791771},
  journal      = {J. Nucl. Med.; (United States)},
number       = ,

  volume       = 26:5,

  place        = {United States},

  year         = {Wed May 01 00:00:00 EDT 1985},

  month        = {Wed May 01 00:00:00 EDT 1985}

}

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