Bone-seeking properties of Tc-99m carbonyl diphosphonic acid, dihydroxy-methylene diphosphonic acid, and monohydroxy-methylene phosphonic acid: concise communication

Journal Article · Fri Aug 01 00:00:00 EDT 1980 · J. Nucl. Med.; (United States)

OSTI ID:6791545

Wang, T S.T.; Fawwaz, R A; Johnson, L J; Mojdehi, G E; Johnson, P M

Carbonyl diphosphonic acid, dihydroxy-methylene diphosphonic acid and monohydroxy-methylene diphosphonic acid were synthesized and labeled with Tc-99m. Their chemical structures were confirmed and their bone-seeking relationships were compared with those of Tc-99m MDP in experimental animals. Monohydroxymethylene diphosphonic acid was found to have higher bone affinity and faster blood clearance than MDP, whereas carbonyl diphosphonic acid and dihydroxymethylene diphosphonic acid demonstrated lower bone affinity and slower blood clearance than MDP.

• Research Organization: Columbia-Presbyterian Medical Center, New York, NY
• OSTI ID: 6791545
• Journal Information: J. Nucl. Med.; (United States), Vol. 21:8; Conference: 28. annual meeting of the Society of Nuclear Medicine, Las Vegas, NV, USA, 16 Jun 1981
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
PHOSPHONIC ACID ESTERS
RADIOPHARMACEUTICALS
BIOLOGICAL LOCALIZATION
SKELETON
SCINTISCANNING
TECHNETIUM 99
BLOOD-PLASMA CLEARANCE
BONE SEEKERS
CHEMICAL PROPERTIES
COMPARATIVE EVALUATIONS
ISOMERIC NUCLEI
RATS
STRUCTURAL CHEMICAL ANALYSIS
TISSUE DISTRIBUTION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CLEARANCE
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DRUGS
ESTERS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RODENTS
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
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