Hematopoiesis and aging. V. A decline in hematocrit occurs in all aging female B6D2F1 mice
Longitudinal studies of hematocrits were done in aging B6D2F1 female mice at 54, 64, 91, 105 and 115 weeks of age. A modest decline in hematocrit was observed in 41/42 mice; we have previously shown that the decreased hematocrit of aged as compared to young mice is due to an expansion of plasma volume. Mice which died spontaneously after 91 weeks had lower hematocrits at 91 weeks and 105 weeks than did those which survived to 115 weeks. At each time interval, a sub-group of mice was killed and uptake of /sup 59/Fe into blood, foreleg, spleen and liver was studied and total nucleated cells per humerus was determined. The results were generally compatible with the thesis that aging mice maintain normal rates of erythropoiesis under basal conditions. Thus, it would appear that a decrease in hematocrit can be considered an expected part of the aging process in this mouse.
- Research Organization:
- Univ. of Pittsburgh, PA
- OSTI ID:
- 6788387
- Journal Information:
- Exp. Aging Res.; (United States), Vol. 3
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effects of Six Sequential Charged Particle Beams on Behavioral and Cognitive Performance in B6D2F1 Female and Male Mice
Combined Effects of Three High-Energy Charged Particle Beams Important for Space Flight on Brain, Behavioral and Cognitive Endpoints in B6D2F1 Female and Male Mice
Related Subjects
MICE
AGING
BLOOD FORMATION
BLOOD CHEMISTRY
IRON 59
IRON COMPOUNDS
TRACER TECHNIQUES
UPTAKE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
IRON ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NUCLEI
RADIOISOTOPES
RODENTS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques