Activated recombinant adenovirus proteinases

Patent · Tue Aug 10 00:00:00 EDT 1999

OSTI ID:678582

Anderson, C W; Mangel, W F

This application describes methods and expression constructs for producing activatable recombinant adenovirus proteinases. Purified activatable recombinant adenovirus proteinases and methods of purification are described. Activated adenovirus proteinases and methods for obtaining activated adenovirus proteinases are further included. Isolated peptide cofactors of adenovirus proteinase activity, methods of purifying and identifying peptide cofactors are also described. Antibodies immunoreactive with adenovirus proteinases, immunospecific antibodies, and methods for preparing them are also described. Other related methods and materials are also described. 29 figs.

• Sponsoring Organization: USDOE, Washington, DC (United States); National Insts. of Health, Bethesda, MD (United States)
• Assignee: Associated Universities, Inc., Washington, DC (United States)
• Patent Number(s): US 5,935,840/A/
• Application Number: PAN: 8-435,998; CNN: Grant U01 A126049
• OSTI ID: 678582
• Resource Relation: Other Information: PBD: 10 Aug 1999
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
PURIFICATION
PEPTIDE HYDROLASES
ADENOVIRUS
ANTIBODIES
IMMUNE REACTIONS