Inhalation of baby talc powder by hamsters

Wehner, A P; Zwicker, G M; Cannon, W C; Watson, C R

Title: Inhalation of baby talc powder by hamsters

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Abstract

Groups of 50 male and 50 female Syrian golden hamsters are being exposed to baby talc powder aerosol 3 min/day, 30 min/day, and 150 min/day, respectively, for 30 exposure days, and for 30 min/day and 150 min/day, respectively, for 300 exposure days. Mean total aerosol concentration is approximately 28 ..mu..g/l, mean respirable fraction of the aerosol is approximately 8 ..mu..g/l. Two groups of 25 male and 25 female control hamsters are receiving sham exposures 150 min/day for 30 and 300 exposure days, respectively. After the 30- and 300-day exposures the hamsters are being maintained for life span observations. At death, lung, trachea, larynx, liver, kidneys, adrenals, heart, stomach, ovaries and uterus, or testicles, and tissues showing gross lesions, are collected for histopathologic examination. Evaluative criteria are histopathologic findings, life span and body weights. Experimental data and results are incomplete at this time. Final results will be available by spring 1975. Preliminary pathologic evaluation indicates that systemic amyloidosis is the major cause of death in the exposed as well as in the control animals. Kidneys, adrenal glands, and liver are most frequently involved. Inhalation of baby talc powder has caused no obvious pulmonary lesions and no decreased life span in themore »« less

Authors:: Wehner, A P; Zwicker, G M; Cannon, W C; Watson, C R

Publication Date:: Wed Jan 01 00:00:00 EST 1975

OSTI Identifier:: 6783174

Resource Type:: Conference

Resource Relation:: Conference: 18. international congress on occupational health, Brighton, England, 14 Sep 1975

Country of Publication:: United States

Language:: English

Subject:: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; AEROSOLS; INHALATION; TALC; BIOLOGICAL EFFECTS; ADRENAL GLANDS; HAMSTERS; HISTOLOGY; KIDNEYS; LIFE SPAN; LIVER; LUNGS; QUANTITY RATIO; TRACHEA; WEIGHT; ALKALINE EARTH METAL COMPOUNDS; ANIMALS; BODY; COLLOIDS; DIGESTIVE SYSTEM; DISPERSIONS; ENDOCRINE GLANDS; GLANDS; INTAKE; MAGNESIUM COMPOUNDS; MAGNESIUM SILICATES; MAMMALS; MINERALS; ORGANS; OXYGEN COMPOUNDS; RESPIRATORY SYSTEM; RODENTS; SILICATES; SILICON COMPOUNDS; SOLS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)

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                    Wehner, A P, Zwicker, G M, Cannon, W C, and Watson, C R. Inhalation of baby talc powder by hamsters.  United States: N. p., 1975. 
        Web.

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                    Wehner, A P, Zwicker, G M, Cannon, W C, & Watson, C R. Inhalation of baby talc powder by hamsters.  United States.

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                    Wehner, A P, Zwicker, G M, Cannon, W C, and Watson, C R. 1975.  
        "Inhalation of baby talc powder by hamsters".  United States.

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@article{osti_6783174,

  title        = {Inhalation of baby talc powder by hamsters},

  author       = {Wehner, A P and Zwicker, G M and Cannon, W C and Watson, C R},

  abstractNote = {Groups of 50 male and 50 female Syrian golden hamsters are being exposed to baby talc powder aerosol 3 min/day, 30 min/day, and 150 min/day, respectively, for 30 exposure days, and for 30 min/day and 150 min/day, respectively, for 300 exposure days. Mean total aerosol concentration is approximately 28 ..mu..g/l, mean respirable fraction of the aerosol is approximately 8 ..mu..g/l. Two groups of 25 male and 25 female control hamsters are receiving sham exposures 150 min/day for 30 and 300 exposure days, respectively. After the 30- and 300-day exposures the hamsters are being maintained for life span observations. At death, lung, trachea, larynx, liver, kidneys, adrenals, heart, stomach, ovaries and uterus, or testicles, and tissues showing gross lesions, are collected for histopathologic examination. Evaluative criteria are histopathologic findings, life span and body weights. Experimental data and results are incomplete at this time. Final results will be available by spring 1975. Preliminary pathologic evaluation indicates that systemic amyloidosis is the major cause of death in the exposed as well as in the control animals. Kidneys, adrenal glands, and liver are most frequently involved. Inhalation of baby talc powder has caused no obvious pulmonary lesions and no decreased life span in the exposed hamsters evaluated to date as compared with their controls.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/6783174},
  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Wed Jan 01 00:00:00 EST 1975},

  month        = {Wed Jan 01 00:00:00 EST 1975}

}

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