Prediction of response to preoperative radiotherapy in soft tissue tumors by thallium and pyrophosphate
To determine if local perfusion or extent of necrosis in soft tissue tumors could be used to predict response to radiotherapy, a prospective study was performed in patients with malignant soft tissue tumors (all greater than grade 2 stage IIb). Fourteen patients were scanned after injection of 2 mCi of 201-Thalium (T1) and after 20 mCi 99mTc pyrophosphate (PYP). The response of the tumor, expressed as a 30% or greater decrease in the tumor mass, was compared to the local intensity of tracer concentration (tumor/background T/BG). There was a positive correlation in T/BG between T1 and PYP (r=0.72, p<0.01). A decrease of >30% of tumor mass was observed in 9 patients with a mean T1 T/BG of 1.59 +- 0.31 and a PYP of 1.55 +- 0.57. Tumors with poor perfusion and limited necrosis had significant volume reductions to radiotherapy, while those with greater perfusion and more extensive necrosis did not. These results suggest that either thallium of pyrophosphate can be used to predict a decrease in volume of tumor from preoperative radiotherapy in patients with soft tissue tumors.
- Research Organization:
- Massachusetts General Hospital, Boston, MA
- OSTI ID:
- 6778494
- Report Number(s):
- CONF-840619-
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ANIMAL TISSUES
NEOPLASMS
RADIOTHERAPY
PHOSPHATES
LABELLING
THERAPEUTIC USES
TECHNETIUM 99
THALLIUM 201
NECROSIS
PATIENTS
QUANTITY RATIO
SURGERY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PHOSPHORUS COMPOUNDS
RADIOISOTOPES
RADIOLOGY
SECONDS LIVING RADIOISOTOPES
TECHNETIUM ISOTOPES
THALLIUM ISOTOPES
THERAPY
TISSUES
USES
YEARS LIVING RADIOISOTOPES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)