Discordance between blood flow and fatty acid uptake in the myocardium following lactate infusion
The uptake of metabolic substrates by the heart is dependent, in part, on the concentration of alternative substrates in the blood. To determine the effect of increasing blood concentrations of lactate (L) on the myocardial concentration of fatty acid, studies were performed in 5 closed chest, anesthetized dogs. A modified fatty acid, 14-p-(I-123)iodophenyl beta methyl tetradecanoic acid (BMFA), which is taken up by the cell but does not undergo beta oxidation, was compared to Tl-201, a marker of perfusion. Two sets of measurements were made: (a) basal Tl and BMFA; followed by infusion of L and (b) reinjection of Tl and BMFA. Sequential 1 minute images were collected for 32 minutes after injection of each tracer, corrected for background activity, and analyzed to produce time/activity curves from the myocardium. A ratio of BMFA/Tl at 10 minutes after injection was calculated. BMFA/Tl was 1.33 +- 31 (mean +- SD) pre L and decreased to 0.72 +- 12 post L. The Tl values before and after L remained essentially unchanged. In conclusion, there is a discordance between myocardial blood flow (Tl) and BMFA distribution following L infusion. The change in BMFA/Tl ratio suggests that elevated L decreases BMFA concentration in the heart.
- Research Organization:
- Massachusetts General Hospital, Boston, MA
- OSTI ID:
- 6778091
- Report Number(s):
- CONF-840619-
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LACTATES
BIOLOGICAL EFFECTS
INFUSION
MONOCARBOXYLIC ACIDS
UPTAKE
MYOCARDIUM
BLOOD FLOW
DOGS
METABOLISM
OXIDATION
SUBSTRATES
ANIMALS
BODY
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CHEMICAL REACTIONS
HEART
INTAKE
MAMMALS
MUSCLES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
VERTEBRATES
551000* - Physiological Systems