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Title: B cell acute lymphoblastic leukemia (ALL) with a 14q+ chromosome abnormality

Abstract

An adult patient with acute lymphoblastic leukemia associated with a 14q+ marker chromosome is presented. The abnormally resulted from a translocation of material from the long arm of chromosome 11. The leukemic cells were found to be B cells on the basis of surface immunoglobulins, lack of receptors for sheep erythrocytes, and a characteristically low level of adenosine deaminase activity. In other patients with ALL studied by us or reported by others in whom chromosome banding was done, a 14q+ chromosome was present in only one instance, also a case of B cell ALL. The frequency occurrence of a 14q+ chromosome in other malignant lymphoproliferative diseases of B cell origin suggests that a general association may exist between the 14q+ abnormality and B cell neoplasms. Cytogenetic analysis may therefore be useful in defining subtypes of ALL and in relating specific chromosomal abnormalities to lymphoproliferative disorders.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Univ. of Chicago, IL
OSTI Identifier:
6773954
Alternate Identifier(s):
OSTI ID: 6773954
DOE Contract Number:  
EY-76-C-02-0069
Resource Type:
Journal Article
Journal Name:
Blood; (United States)
Additional Journal Information:
Journal Volume: 53:2
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; BANDING TECHNIQUES; DIAGNOSTIC USES; CHROMOSOMES; BIOLOGICAL EFFECTS; LEUKEMIA; SIDE EFFECTS; LYMPHOCYTES; CHROMOSOMAL ABERRATIONS; IMMUNOGLOBULINS; PATIENTS; ANIMAL CELLS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DISEASES; GLOBULINS; HEMIC DISEASES; LEUKOCYTES; MATERIALS; MUTATIONS; NEOPLASMS; ORGANIC COMPOUNDS; PROTEINS; SOMATIC CELLS; USES 550400* -- Genetics

Citation Formats

Roth, D.G., Cimino, M.C., Variakojis, D., Golomb, H.M., and Rowley, J.D. B cell acute lymphoblastic leukemia (ALL) with a 14q+ chromosome abnormality. United States: N. p., 1979. Web.
Roth, D.G., Cimino, M.C., Variakojis, D., Golomb, H.M., & Rowley, J.D. B cell acute lymphoblastic leukemia (ALL) with a 14q+ chromosome abnormality. United States.
Roth, D.G., Cimino, M.C., Variakojis, D., Golomb, H.M., and Rowley, J.D. Thu . "B cell acute lymphoblastic leukemia (ALL) with a 14q+ chromosome abnormality". United States.
@article{osti_6773954,
title = {B cell acute lymphoblastic leukemia (ALL) with a 14q+ chromosome abnormality},
author = {Roth, D.G. and Cimino, M.C. and Variakojis, D. and Golomb, H.M. and Rowley, J.D.},
abstractNote = {An adult patient with acute lymphoblastic leukemia associated with a 14q+ marker chromosome is presented. The abnormally resulted from a translocation of material from the long arm of chromosome 11. The leukemic cells were found to be B cells on the basis of surface immunoglobulins, lack of receptors for sheep erythrocytes, and a characteristically low level of adenosine deaminase activity. In other patients with ALL studied by us or reported by others in whom chromosome banding was done, a 14q+ chromosome was present in only one instance, also a case of B cell ALL. The frequency occurrence of a 14q+ chromosome in other malignant lymphoproliferative diseases of B cell origin suggests that a general association may exist between the 14q+ abnormality and B cell neoplasms. Cytogenetic analysis may therefore be useful in defining subtypes of ALL and in relating specific chromosomal abnormalities to lymphoproliferative disorders.},
doi = {},
journal = {Blood; (United States)},
number = ,
volume = 53:2,
place = {United States},
year = {1979},
month = {2}
}