A study of the FDG model in the presence of an altered blood brain barrier (BBB) and glucose metabolic/flow relationships in human brain tumors with PET
The authors performed 3 hour kinetic FDG studies (5 parameter model, 5th parameter represents cerebral blood volume (CBV) on 8 patients with primary or metastatic brain tumors. One subject also had a direct measurement of BBB permeability with Ga-68 EDTA and 5 subjects also had cerebral blood flow (CBF) determinations with bolus injections of 0-15 water. Estimates of hexose distribution volumes (HDV=k/sub 1/*/k/sub 2/*), FDG distribution volumes (DV=k/sub 1/*/(k/sub 2/*+k/sub 3/*), a ratio R=k/sub 3/*k/sub 2/* that is related to the stability of the lumped constant (LC) and glucose extraction ratios (GER) were calculated. GER averaged 8.8 (+- 4.6)% in tumors, 7.7 (+- 1.7)% in gray matter, 10.3 (+- 3.8)% in white matter and 8.4 (+- 2.1)% in hemispheric regions. R averaged 0.46 (+- 0.19) in tumors, 0.47 (+- 0.24) in gray matter, 0.45 (+- 0.18) in white matter and 0.57 (+- 0.25) in hemispheric regions. HDV estimates were 0.33 (+- 0.11) in tumors, 0.48 (+- 0.25) in gray matter, 0.34 (+- 0.14) in white matter and 0.38 (+- 0.25) in hemispheric regions. DV estimates were smaller than HDV but were not significantly different over the same groups. These results suggest that the compartmental configuration of the FDG model is still appropriate in this set of patients with increased BBB permeability and that LC is relatively stable. A lack of significant increase in the FDG rate constants k/sub 1/* and k/sub 2/* with increases BBB permeability suggests that facilitated diffusion remains the dominant mechanism of glucose transport even with BBB abnormalities.
- Research Organization:
- UCLA School of Medicine, Los Angeles, CA
- OSTI ID:
- 6760748
- Report Number(s):
- CONF-850611-; TRN: 87-010637
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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BLOOD-BRAIN BARRIER
PERMEABILITY
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BLOOD FLOW
METABOLISM
NEOPLASMS
POSITRON COMPUTED TOMOGRAPHY
FLUORODEOXYGLUCOSE
LABELLING
CHEMICAL REACTION KINETICS
DYNAMIC FUNCTION STUDIES
GLUCOSE
MATHEMATICAL MODELS
PATIENTS
RADIONUCLIDE KINETICS
ALDEHYDES
ANTIMETABOLITES
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CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
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DRUGS
EMISSION COMPUTED TOMOGRAPHY
HEXOSES
KINETICS
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
REACTION KINETICS
SACCHARIDES
TOMOGRAPHY
550601* - Medicine- Unsealed Radionuclides in Diagnostics