skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Metallothaionein in the extracellular fluids as an index of cadmium toxicity

Abstract

In rats injected with CdCl2 5 days/week, metallothionein was detected in plasma by gel filtration chromatography as early as four weeks. Signs of renal toxicity were evident from gluocosuria and proteinuria. The excretion of cadmium in urine at this time was rather low. The amount of metallothionein in plasma, as determined by /sup 109/Cd-binding to the 10,000 molecular weight fraction, increased markedly during week 14. Signs of renal toxicity were were evident from glucosuria and proteinuria. The excretion of cadmium in urine increased markedly and the majority of it was in the form of metallothionein. It is suggested that the appearance of metallothionein in plasma and urine can be used as specific indices of cadmium poisoning and that the assay of the protein in these fluids may be useful in screening for excessive cadmium exposure.

Authors:
;
Publication Date:
Research Org.:
Univ. of Rochester, NY
OSTI Identifier:
6758542
Alternate Identifier(s):
OSTI ID: 6758542
Resource Type:
Journal Article
Journal Name:
Environ. Health Perspect.; (United States)
Additional Journal Information:
Journal Volume: 28
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; KIDNEYS; RADIONUCLIDE KINETICS; LIVER; TOXICITY; DIAGNOSIS; BLOOD PLASMA; CADMIUM 109; CADMIUM CHLORIDES; LABELLED COMPOUNDS; PROTEINS; RATS; TRACER TECHNIQUES; URINE; UROGENITAL SYSTEM DISEASES; ANIMALS; BETA DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BLOOD; BODY; BODY FLUIDS; CADMIUM COMPOUNDS; CADMIUM HALIDES; CADMIUM ISOTOPES; CHLORIDES; CHLORINE COMPOUNDS; DIGESTIVE SYSTEM; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; GLANDS; HALIDES; HALOGEN COMPOUNDS; INTERMEDIATE MASS NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; MATERIALS; NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIOISOTOPES; RODENTS; VERTEBRATES; WASTES; YEARS LIVING RADIOISOTOPES 560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)

Citation Formats

Shaikh, Z.A., and Hirayama, K. Metallothaionein in the extracellular fluids as an index of cadmium toxicity. United States: N. p., 1979. Web. doi:10.1289/ehp.7928267.
Shaikh, Z.A., & Hirayama, K. Metallothaionein in the extracellular fluids as an index of cadmium toxicity. United States. doi:10.1289/ehp.7928267.
Shaikh, Z.A., and Hirayama, K. Thu . "Metallothaionein in the extracellular fluids as an index of cadmium toxicity". United States. doi:10.1289/ehp.7928267.
@article{osti_6758542,
title = {Metallothaionein in the extracellular fluids as an index of cadmium toxicity},
author = {Shaikh, Z.A. and Hirayama, K.},
abstractNote = {In rats injected with CdCl2 5 days/week, metallothionein was detected in plasma by gel filtration chromatography as early as four weeks. Signs of renal toxicity were evident from gluocosuria and proteinuria. The excretion of cadmium in urine at this time was rather low. The amount of metallothionein in plasma, as determined by /sup 109/Cd-binding to the 10,000 molecular weight fraction, increased markedly during week 14. Signs of renal toxicity were were evident from glucosuria and proteinuria. The excretion of cadmium in urine increased markedly and the majority of it was in the form of metallothionein. It is suggested that the appearance of metallothionein in plasma and urine can be used as specific indices of cadmium poisoning and that the assay of the protein in these fluids may be useful in screening for excessive cadmium exposure.},
doi = {10.1289/ehp.7928267},
journal = {Environ. Health Perspect.; (United States)},
number = ,
volume = 28,
place = {United States},
year = {1979},
month = {2}
}