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Title: Identification and localization of microsatellite markers covering human chromosome 18

Abstract

To generate microsatellite markers from chromosome 18, the authors have cytogenetically localized a large number of [lambda] phage using a deletion mapping panel of somatic cell hybrids. Here they describe the identification of 65 new CA-repeat-containing phage and the localization of five markers developed in other laboratories. This approach allows the selection of a subset of markers that are well spaced across the chromosome and can be developed as genetic markers. The use of PCR-based markers should allow for the rapid genomic screening of disease genes on chromosome 18. 11 refs., 1 fig., 1 tab.

Authors:
; ; ; ;  [1]; ;  [2]
  1. Thomas Jefferson Univ., Philadelphia, PA (United States)
  2. Columbia Univ., New York, NY (United States)
Publication Date:
OSTI Identifier:
6758453
Resource Type:
Journal Article
Journal Name:
Genomics; (United States)
Additional Journal Information:
Journal Volume: 14:4; Journal ID: ISSN 0888-7543
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; BIOLOGICAL MARKERS; GENETIC MAPPING; HUMAN CHROMOSOME 18; CHROMOSOMES; HUMAN CHROMOSOMES; MAPPING; 550400* - Genetics

Citation Formats

Rojas, K, Kurtz, A, Feder, M, Mewar, R, Overhauser, J, Straub, R E, and Gilliam, T C. Identification and localization of microsatellite markers covering human chromosome 18. United States: N. p., 1992. Web. doi:10.1016/S0888-7543(05)80136-3.
Rojas, K, Kurtz, A, Feder, M, Mewar, R, Overhauser, J, Straub, R E, & Gilliam, T C. Identification and localization of microsatellite markers covering human chromosome 18. United States. https://doi.org/10.1016/S0888-7543(05)80136-3
Rojas, K, Kurtz, A, Feder, M, Mewar, R, Overhauser, J, Straub, R E, and Gilliam, T C. 1992. "Identification and localization of microsatellite markers covering human chromosome 18". United States. https://doi.org/10.1016/S0888-7543(05)80136-3.
@article{osti_6758453,
title = {Identification and localization of microsatellite markers covering human chromosome 18},
author = {Rojas, K and Kurtz, A and Feder, M and Mewar, R and Overhauser, J and Straub, R E and Gilliam, T C},
abstractNote = {To generate microsatellite markers from chromosome 18, the authors have cytogenetically localized a large number of [lambda] phage using a deletion mapping panel of somatic cell hybrids. Here they describe the identification of 65 new CA-repeat-containing phage and the localization of five markers developed in other laboratories. This approach allows the selection of a subset of markers that are well spaced across the chromosome and can be developed as genetic markers. The use of PCR-based markers should allow for the rapid genomic screening of disease genes on chromosome 18. 11 refs., 1 fig., 1 tab.},
doi = {10.1016/S0888-7543(05)80136-3},
url = {https://www.osti.gov/biblio/6758453}, journal = {Genomics; (United States)},
issn = {0888-7543},
number = ,
volume = 14:4,
place = {United States},
year = {Tue Dec 01 00:00:00 EST 1992},
month = {Tue Dec 01 00:00:00 EST 1992}
}