Cadmium inhibits IL-6 production and IL-6 mRNA expression in a human monocytic cell line, THP-1
- Univ. of California, Los Angeles, CA (United States)
Cadmium is a known immunotoxic agent in animal studies. Cells of the mononuclear phagocytic system are strategically located at portals of entry in humans and therefore may be particularly at risk for cadmium exposure through contaminated air, food, and drinking water. The purpose of this study was to determine whether there were changes in interleukin-6 (IL-6) production, a pleiotropic cytokine, when an activated human monocytic cell line was exposed to cadmium. Results suggest that there were statistically significant lower levels of IL-6 at 0.06 mM cadmium (P < 0.05), and 0.8 and 0.1 mM cadmium (P < 0.01), determined via the ELISA method. IL-6 messenger RNA (mRNA) levels were also decreased at these cadmium concentrations. The addition of a chelating agent, EDTA, to the cultures prevented the suppression of IL-6 secretion. 33 refs., 4 figs.
- OSTI ID:
- 6755246
- Journal Information:
- Environmental Progress; (United States), Vol. 66:1; ISSN 0278-4491
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
CADMIUM
TOXICITY
EDTA
RESPONSE MODIFYING FACTORS
MONOCYTES
IMMUNE REACTIONS
IMMUNOSUPPRESSION
MACROPHAGES
AMINO ACIDS
ANIMAL CELLS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOXYLIC ACIDS
CHELATING AGENTS
CONNECTIVE TISSUE CELLS
ELEMENTS
LEUKOCYTES
MATERIALS
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
PHAGOCYTES
SOMATIC CELLS
560300* - Chemicals Metabolism & Toxicology
550200 - Biochemistry