Chemical protection against the long-term effects of a single whole-body exposure of mice to ionizing radiation. II. Causes of death. [X rays]
Male BALB/c or C57Bl mice were exposed to different doses of x rays. Certain groups were given a mixture of protectors or AET prior to irradiation; others served as controls. The animals were followed until spontaneous death, and the lethal diseases were classified as thymic lymphoma, nonthymic lymphoma, reticulosarcoma, myeloid leukemia, lung carcinoma, liver tumors, sarcoma, glomerulosclerosis, noncancerous lung lesions, and others. The data were evaluated by the method of competing risks. Death in nonirradiated BALB/c mice is largely caused by tumors, in particular by lung cancer and nonthymic lymphoma, whereas other causes predominate in the C57Bl strain. Radiation-induced life shortening of nonprotected mice is due to increased and advanced incidences of specific diseases, mainly thymic lymphoma in the medium dose range and glomerulosclerosis in the high dose range. Thymic lymphoma in BALB/c mice increases to a maximum at 650 R and declines thereafter. A shorter latency period is found for lung carcinoma, although the absolute incidence decreases because of the earlier deaths of the irradiated mice. After AET treatment the maximum incidence of thymic lymphoma in BALB/c mice is shifted to 1000 R but its height is unaltered, whereas treatment with a mixture not only displaces the maximum to a still higher dose but also decreases its frequency. Protection in BALB/c mice is also possible, although to a smaller extent, against myeloid leukemia, sarcoma, glomerulosclerosis, and noncancerous lung lesions but it is protection against the two latter diseases which contributes most to the prolonged survival in the high dose range. The protection in C57Bl mice resembles that in the BALB/c strain. Thus protection is effective against thymic lymphoma (possibly also against liver adenomas, all carcinomas, and myeloid leukemia) as well as against glomerulosclerosis and noncancerous lung lesions.
- Research Organization:
- CEN, Mol, Belgium
- OSTI ID:
- 6751701
- Journal Information:
- Radiat. Res.; (United States), Vol. 74:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ADENOMAS
RADIOINDUCTION
AET
RADIOSENSITIVITY EFFECTS
CARCINOMAS
CYSTEINE
GLOMERULI
BIOLOGICAL RADIATION EFFECTS
GLUTATHIONE
LEUKEMIA
LIFE SPAN
LIVER
LUNGS
LYMPHOMAS
MEA
NEPHROSCLEROSIS
RESPIRATORY SYSTEM DISEASES
RETICULOENDOTHELIAL SYSTEM
SARCOMAS
SEROTONIN
THYMUS
ACUTE IRRADIATION
DOSE-RESPONSE RELATIONSHIPS
MICE
WHOLE-BODY IRRADIATION
X RADIATION
ACUTE EXPOSURE
AMINES
AMINO ACIDS
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
BODY
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
DIGESTIVE SYSTEM
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GLANDS
HEMIC DISEASES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
IONIZING RADIATIONS
IRRADIATION
KIDNEYS
LYMPHATIC SYSTEM
MAMMALS
NEOPLASMS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PEPTIDES
POLYPEPTIDES
PROTEINS
PYRROLES
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
RESPONSE MODIFYING FACTORS
RODENTS
SYMPATHOMIMETICS
THIOLS
THIOUREAS
TISSUES
TRYPTAMINES
UROGENITAL SYSTEM DISEASES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals