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Title: Computer simulation of metal ion equilibria in biofluids. IV. Plutonium speciation in human blood plasma and chelation therapy using polyaminopolycarboxylic acids

Abstract

An investigation by computer simulation into the nature of Pu(IV) binding to low-molecular ligands in human blood plasma is described. Particular consideration is given to the interactions of various chelating agents which have been or might be used for treating plutonium intoxication. Formation constants of EDTA and DTPA with Cu(II), Mg(II), Mn(II), Zn(II), and Cd(II) have been measured under biologic conditions of temperature and background electrolyte. The relative ability of these and other chelating agents to cause excretion of plutonium and the concomitant loss of certain essential trace metals has thus been assessed.

Authors:
; ;
Publication Date:
Research Org.:
University of Wales Institute of Science and Technology, UK
OSTI Identifier:
6748458
Resource Type:
Journal Article
Journal Name:
J. Inorg. Biochem.; (United States)
Additional Journal Information:
Journal Volume: 20:3
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CLEARANCE; COMPUTERIZED SIMULATION; PLUTONIUM; BLOOD PLASMA; CHELATING AGENTS; DTPA; EDTA; ACTINIDES; AMINO ACIDS; BIOLOGICAL MATERIALS; BLOOD; BODY FLUIDS; CARBOXYLIC ACIDS; DRUGS; ELEMENTS; MATERIALS; METALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOPROTECTIVE SUBSTANCES; SIMULATION; TRANSURANIUM ELEMENTS; 560170* - Radiation Effects- Nuclide Kinetics & Toxicology- (-1987)

Citation Formats

Duffield, J R, May, P M, and Williams, D R. Computer simulation of metal ion equilibria in biofluids. IV. Plutonium speciation in human blood plasma and chelation therapy using polyaminopolycarboxylic acids. United States: N. p., 1984. Web. doi:10.1016/0162-0134(84)85019-9.
Duffield, J R, May, P M, & Williams, D R. Computer simulation of metal ion equilibria in biofluids. IV. Plutonium speciation in human blood plasma and chelation therapy using polyaminopolycarboxylic acids. United States. https://doi.org/10.1016/0162-0134(84)85019-9
Duffield, J R, May, P M, and Williams, D R. 1984. "Computer simulation of metal ion equilibria in biofluids. IV. Plutonium speciation in human blood plasma and chelation therapy using polyaminopolycarboxylic acids". United States. https://doi.org/10.1016/0162-0134(84)85019-9.
@article{osti_6748458,
title = {Computer simulation of metal ion equilibria in biofluids. IV. Plutonium speciation in human blood plasma and chelation therapy using polyaminopolycarboxylic acids},
author = {Duffield, J R and May, P M and Williams, D R},
abstractNote = {An investigation by computer simulation into the nature of Pu(IV) binding to low-molecular ligands in human blood plasma is described. Particular consideration is given to the interactions of various chelating agents which have been or might be used for treating plutonium intoxication. Formation constants of EDTA and DTPA with Cu(II), Mg(II), Mn(II), Zn(II), and Cd(II) have been measured under biologic conditions of temperature and background electrolyte. The relative ability of these and other chelating agents to cause excretion of plutonium and the concomitant loss of certain essential trace metals has thus been assessed.},
doi = {10.1016/0162-0134(84)85019-9},
url = {https://www.osti.gov/biblio/6748458}, journal = {J. Inorg. Biochem.; (United States)},
number = ,
volume = 20:3,
place = {United States},
year = {Thu Mar 01 00:00:00 EST 1984},
month = {Thu Mar 01 00:00:00 EST 1984}
}