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Title: Radiolabelled D/sub 2/ agonists as prolactinoma imaging agents: Progress report for period February 1, 1988--January 31, 1989

Abstract

Targeted studies completed include the evaluation of tritiated N-0437, evaluation of /sup 35/S-cysteamine, evaluation of /sup 18/F-FDG and initiation of synthetic efforts towards the synthesis of iodinated N-0437 and pergolide analogs. The direction of the project has been changed due to several factors which include the decided lack of favorable experimental results, the excellence of results using muscarinic receptor ligands in pituitary, brain and heart and the contention of the DOE review panel that the original grant proposal was based on flawed assumptions together with their perceived lack of importance to pituitary imaging. In the final year of this grant, three studies will be completed. The first study is the continuation of synthetic efforts to prepare iodinated N-0437 and pergolide analogs for possible use as brain imaging agents. The second study is directed towards completion of biochemical evaluation of various muscarinic receptor analogs for heart, brain and (possible) pituitary imaging. The third study is to probe the use of quaternized D/sub 2/ receptor ligands for imaging peripheral dopaminergic receptors (including the pituitary). 14 refs., 1 fig., 7 tabs.

Authors:
Publication Date:
Research Org.:
Michigan Univ., Dearborn (USA)
OSTI Identifier:
6745760
Alternate Identifier(s):
OSTI ID: 6745760; Legacy ID: DE89001793
Report Number(s):
DOE/ER/60528-2
ON: DE89001793; TRN: 88-035766
DOE Contract Number:  
FG02-87ER60528
Resource Type:
Technical Report
Resource Relation:
Other Information: Portions of this document are illegible in microfiche products
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; NEOPLASMS; POSITRON COMPUTED TOMOGRAPHY; PITUITARY GLAND; CYSTAMINE; DOPAMINE; ERGOTAMINE; FLUORODEOXYGLUCOSE; HALLUCINOGENS; MORPHINE; PROGRESS REPORT; RADIOPHARMACEUTICALS; RATS; SULFUR 35; TRITIUM COMPOUNDS; VASOCONSTRICTORS; ALKALOIDS; AMINES; ANALGESICS; ANIMALS; ANTIMETABOLITES; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARDIOTONICS; CARDIOVASCULAR AGENTS; CENTRAL NERVOUS SYSTEM AGENTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; COMPUTERIZED TOMOGRAPHY; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DOCUMENT TYPES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; ENDOCRINE GLANDS; EVEN-ODD NUCLEI; GLANDS; HYDROXY COMPOUNDS; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MAMMALS; NARCOTICS; NEUROREGULATORS; NUCLEI; OPIUM; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; PHENOLS; POLYPHENOLS; PSYCHOTROPIC DRUGS; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RODENTS; SULFUR ISOTOPES; SYMPATHOLYTICS; SYMPATHOMIMETICS; TOMOGRAPHY; VERTEBRATES 550602* -- Medicine-- External Radiation in Diagnostics-- (1980-); 550501 -- Metabolism-- Tracer Techniques

Citation Formats

Otto, C.A. Radiolabelled D/sub 2/ agonists as prolactinoma imaging agents: Progress report for period February 1, 1988--January 31, 1989. United States: N. p., 1988. Web.
Otto, C.A. Radiolabelled D/sub 2/ agonists as prolactinoma imaging agents: Progress report for period February 1, 1988--January 31, 1989. United States.
Otto, C.A. Sat . "Radiolabelled D/sub 2/ agonists as prolactinoma imaging agents: Progress report for period February 1, 1988--January 31, 1989". United States.
@article{osti_6745760,
title = {Radiolabelled D/sub 2/ agonists as prolactinoma imaging agents: Progress report for period February 1, 1988--January 31, 1989},
author = {Otto, C.A.},
abstractNote = {Targeted studies completed include the evaluation of tritiated N-0437, evaluation of /sup 35/S-cysteamine, evaluation of /sup 18/F-FDG and initiation of synthetic efforts towards the synthesis of iodinated N-0437 and pergolide analogs. The direction of the project has been changed due to several factors which include the decided lack of favorable experimental results, the excellence of results using muscarinic receptor ligands in pituitary, brain and heart and the contention of the DOE review panel that the original grant proposal was based on flawed assumptions together with their perceived lack of importance to pituitary imaging. In the final year of this grant, three studies will be completed. The first study is the continuation of synthetic efforts to prepare iodinated N-0437 and pergolide analogs for possible use as brain imaging agents. The second study is directed towards completion of biochemical evaluation of various muscarinic receptor analogs for heart, brain and (possible) pituitary imaging. The third study is to probe the use of quaternized D/sub 2/ receptor ligands for imaging peripheral dopaminergic receptors (including the pituitary). 14 refs., 1 fig., 7 tabs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1988},
month = {10}
}

Technical Report:
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