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Title: Microprobe analysis of chlorpromazine pigmentation

Abstract

We describe the histochemical, ultrastructural, and microanalytical features of a skin biopsy specimen obtained from a patient with chlorpromazine pigmentation. Golden-brown pigment granules were present in the dermis, predominantly in a perivascular arrangement. The granules stained positively with the Fontana-Masson stain for silver-reducing substances and negatively with Perl's stain for iron. Electron microscopy revealed dense inclusion bodies in dermal histiocytes, pericytes, endothelial cells, and Schwann cells, as well as lying free in the extracellular matrix. These ''chlorpromazine bodies'' were quite dense even in unosmicated, unstained ultrathin sections, indicating that the pigmentation is related, at least in part, to the inclusions. Microprobe analysis of the chlorpromazine bodies revealed a striking peak for sulfur, which strongly suggests the presence of the drug or its metabolite within these inclusions.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Duke Univ. Medical Center, Durham, NC (USA)
OSTI Identifier:
6745356
Alternate Identifier(s):
OSTI ID: 6745356
Resource Type:
Journal Article
Resource Relation:
Journal Name: Arch. Dermatol.; (United States); Journal Volume: 124:10
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; CHLORPROMAZINE; ELECTRON MICROPROBE ANALYSIS; SKIN; PIGMENTS; BIOPSY; MOLECULAR STRUCTURE; PATIENTS; STAINS; AMINES; AZINES; BODY; CENTRAL NERVOUS SYSTEM AGENTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CHEMICAL ANALYSIS; DIAGNOSTIC TECHNIQUES; DRUGS; HETEROCYCLIC COMPOUNDS; HYPNOTICS AND SEDATIVES; MICROANALYSIS; ORGANIC CHLORINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; PHENOTHIAZINES; PSYCHOTROPIC DRUGS; TRANQUILIZERS 550901* -- Pathology-- Tracer Techniques

Citation Formats

Benning, T.L., McCormack, K.M., Ingram, P., Kaplan, D.L., and Shelburne, J.D. Microprobe analysis of chlorpromazine pigmentation. United States: N. p., 1988. Web. doi:10.1001/archderm.124.10.1541.
Benning, T.L., McCormack, K.M., Ingram, P., Kaplan, D.L., & Shelburne, J.D. Microprobe analysis of chlorpromazine pigmentation. United States. doi:10.1001/archderm.124.10.1541.
Benning, T.L., McCormack, K.M., Ingram, P., Kaplan, D.L., and Shelburne, J.D. Sat . "Microprobe analysis of chlorpromazine pigmentation". United States. doi:10.1001/archderm.124.10.1541.
@article{osti_6745356,
title = {Microprobe analysis of chlorpromazine pigmentation},
author = {Benning, T.L. and McCormack, K.M. and Ingram, P. and Kaplan, D.L. and Shelburne, J.D.},
abstractNote = {We describe the histochemical, ultrastructural, and microanalytical features of a skin biopsy specimen obtained from a patient with chlorpromazine pigmentation. Golden-brown pigment granules were present in the dermis, predominantly in a perivascular arrangement. The granules stained positively with the Fontana-Masson stain for silver-reducing substances and negatively with Perl's stain for iron. Electron microscopy revealed dense inclusion bodies in dermal histiocytes, pericytes, endothelial cells, and Schwann cells, as well as lying free in the extracellular matrix. These ''chlorpromazine bodies'' were quite dense even in unosmicated, unstained ultrathin sections, indicating that the pigmentation is related, at least in part, to the inclusions. Microprobe analysis of the chlorpromazine bodies revealed a striking peak for sulfur, which strongly suggests the presence of the drug or its metabolite within these inclusions.},
doi = {10.1001/archderm.124.10.1541},
journal = {Arch. Dermatol.; (United States)},
number = ,
volume = 124:10,
place = {United States},
year = {Sat Oct 01 00:00:00 EDT 1988},
month = {Sat Oct 01 00:00:00 EDT 1988}
}