Influence of cadmium on salt-induced hypertension in Dahl hypertension-sensitive rats
This study investigated the influence of cadmium (Cd) on the pathogenesis of salt-induced hypertension in Dahl hypertension-sensitive (S) rats bred for susceptibility to the hypertensive effect of excess dietary salt (NaCl). Weanling female S rats were divided into two groups. The rats in the Cd group received 2 mg Cd/kg ip on week 3 (3 weeks of age) followed by 2nd and 3rd injections of 1 mg Cd/kg on weeks 6 and 23. The controls received the same volume of 0.9% aqueous NaCl ip. A high salt (4% NaCl) diet and tap water were available ad libitum. Cd enhanced the rate and the degree at which salt-induced hypertension developed (week 7), leading to an accelerated phase (week 24) associated with a mean systolic blood pressure of 245 mm Hg and drastically increased morbidity and mortality. Conversely, the hypertensive process in the controls averaging a blood pressure of 207 mm Hg was not heralded by other discernible toxic manifestations. Pathological lesions of periarteritis nodosa in the mesenteric arteries and nephrosclerosis occurred to the same extent in the Cd and control groups. This study demonstrated that Cd exacerbated the severity of salt-induced hypertension in S rats.
- Research Organization:
- Brookhaven National Lab., Upton, N.Y. (USA)
- DOE Contract Number:
- EY-76-C-02-0016
- OSTI ID:
- 6741033
- Report Number(s):
- BNL-24337; CONF-780631-1
- Resource Relation:
- Conference: 12. conference on trace substances, Columbia, MO, USA, 5 Jun 1978
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
CADMIUM
BIOLOGICAL EFFECTS
HYPERTENSION
PATHOLOGICAL CHANGES
SODIUM CHLORIDES
BLOOD PRESSURE
DIET
MORTALITY
RATS
SENSITIVITY
SYNERGISM
ALKALI METAL COMPOUNDS
ANIMALS
CARDIOVASCULAR DISEASES
CHLORIDES
CHLORINE COMPOUNDS
DISEASES
ELEMENTS
HALIDES
HALOGEN COMPOUNDS
MAMMALS
METALS
RODENTS
SODIUM COMPOUNDS
SYMPTOMS
VASCULAR DISEASES
VERTEBRATES
560400* - Other Environmental Pollutant Effects
551000 - Physiological Systems