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Title: Pathogenesis of veno-occlusive liver disease after radiation

Abstract

Radiation-induced liver disease is characterized structurally by progressive fibrous obliteration of central veins (veno-occlusive disease (VOD)). The pathogenesis is unknown. Samples of liver from 11 patients with radiation-induced VOD were studied by light and electron microscopy for evidence of central vein thrombosis. The patients had received fractionated radiation with total doses of 1850 to 4050 rads, or single doses of 1000 rads. In addition, six patients had received chemotherapy. We postulate that ionizing radiation injures preferentially the endothelial cells of central veins, which leads to focal deposition of fibrin. The resulting fibrin network is eventually replaced by collagen, causing fibrous occlusion.

Authors:
;
Publication Date:
Research Org.:
Stanford Univ., CA
OSTI Identifier:
6740948
Resource Type:
Journal Article
Resource Relation:
Journal Name: Arch. Pathol. Lab. Med.; (United States); Journal Volume: 104:11
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; FIBROSIS; RADIOINDUCTION; LIVER; DELAYED RADIATION EFFECTS; RADIOTHERAPY; SIDE EFFECTS; VEINS; TRANSMISSION ELECTRON MICROSCOPY; ACUTE IRRADIATION; CHEMOTHERAPY; COLLAGEN; ENDOXAN; FIBRIN; FLUOROURACILS; FRACTIONATED IRRADIATION; PATIENTS; ACUTE EXPOSURE; ALKYLATING AGENTS; ANTIMETABOLITES; ANTIMITOTIC DRUGS; AZINES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BLOOD COAGULATION FACTORS; BLOOD VESSELS; BODY; CARDIOVASCULAR SYSTEM; DIGESTIVE SYSTEM; DRUGS; ELECTRON MICROSCOPY; GLANDS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; IRRADIATION; MEDICINE; MICROSCOPY; NUCLEAR MEDICINE; ORGANIC COMPOUNDS; ORGANIC FLUORINE COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; PROTEINS; PYRIMIDINES; RADIATION EFFECTS; RADIOLOGY; SCLEROPROTEINS; THERAPY; URACILS 550603* -- Medicine-- External Radiation in Therapy-- (1980-)

Citation Formats

Fajardo, L.F., and Colby, T.V. Pathogenesis of veno-occlusive liver disease after radiation. United States: N. p., 1980. Web.
Fajardo, L.F., & Colby, T.V. Pathogenesis of veno-occlusive liver disease after radiation. United States.
Fajardo, L.F., and Colby, T.V. 1980. "Pathogenesis of veno-occlusive liver disease after radiation". United States. doi:.
@article{osti_6740948,
title = {Pathogenesis of veno-occlusive liver disease after radiation},
author = {Fajardo, L.F. and Colby, T.V.},
abstractNote = {Radiation-induced liver disease is characterized structurally by progressive fibrous obliteration of central veins (veno-occlusive disease (VOD)). The pathogenesis is unknown. Samples of liver from 11 patients with radiation-induced VOD were studied by light and electron microscopy for evidence of central vein thrombosis. The patients had received fractionated radiation with total doses of 1850 to 4050 rads, or single doses of 1000 rads. In addition, six patients had received chemotherapy. We postulate that ionizing radiation injures preferentially the endothelial cells of central veins, which leads to focal deposition of fibrin. The resulting fibrin network is eventually replaced by collagen, causing fibrous occlusion.},
doi = {},
journal = {Arch. Pathol. Lab. Med.; (United States)},
number = ,
volume = 104:11,
place = {United States},
year = 1980,
month =
}
  • A focal hot spot seen on a /sup 113m/In-chloride liver scan in an unusual case of hepatic venoocclusive disease bore striking similarities to scanning patterns in superior vena cava syndrome. The findings are also compared to those reported in Budd-Chiari syndrome. (auth)
  • A liver scan on a patient with biopsy-proven hepatic veno-occlusive disease showed multiple areas of decreased sulfur colloid uptake which were not perfused on the blood pool phase of a pertechnetate bolus study. (auth)
  • Purpose: To retrospectively evaluate the outcome of endovascular treatments for patients with chronic veno-occlusive disease in different vascular beds secondary to Behcet's disease (BD). There are few case reports on the subject, and this is the largest study to date. Materials and Methods: From January 2001 through October 2009, chronic venous occlusions were treated in 10 patients (all male [age range 18-76 years]) with BD using percutaneous transluminal angioplasty and/or stent placement. All patients were symptomatic and had chronic iliofemoral deep venous thrombosis (DVT; n = 5), central venous occlusion (n = 3), or Budd-Chiari syndrome (BCS; n = 2).more » All patients met criteria of the International Study Group on Behcet's Disease. Results: Two of five patients with DVT had unsuccessful recanalization attempts. Three patients had successful recanalization with stent placement. All three veins were occluded within 1 month with unsuccessful reinterventions. Three patients with chronic central venous occlusion had successful recanalization with percutaneous transluminal angioplasty (n = 1) and stent placement (n = 2). Two patients had reocclusion with successful reintervention. Two BCS patients had successful treatment with stent placements. Overall technical success was 69%, and no procedural complications were encountered. None of the patients with chronic DVT had patent veins; however, all patients with central venous occlusion or BCS had patent veins on color Doppler ultrasonography at follow-up ranging from 3 to 48 months after intervention. Conclusion: Endovenous treatment for chronic iliofemoral DVT due to BD had a poor outcome. However, long-term outcome after endovenous treatment for upper-extremity central venous occlusion and BCS syndrome was good.« less