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Title: Stimulation of ultraviolet-induced carcinogenesis by 1,3-bis(2-chloroethyl)-1-nitrosourea

Abstract

The influence of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on ultraviolet-induced carcinogenesis was examined in hairless mouse skin in vivo. Noncarcinogenic amounts of topically applied BCNU and carcinogenic levels of UVB energy were utilized in the study. The applications of BCNU significantly accelerated the appearance and growth of the cutaneous tumors in this study. Thus, the BCNU acted as either a promoting or a cocarcinogenic agent for ultraviolet-induced cancer formation. Although the mechanism of this effect has not been established, avoidance of extensive sun exposure would probably be prudent when topical BCNU is being utilized therapeutically.

Authors:
Publication Date:
Research Org.:
Univ. of California School of Medicine, San Francisco
OSTI Identifier:
6739195
Alternate Identifier(s):
OSTI ID: 6739195
Resource Type:
Journal Article
Journal Name:
Cancer Res.; (United States)
Additional Journal Information:
Journal Volume: 39:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CARCINOGENESIS; RADIOINDUCTION; NITROSO COMPOUNDS; EVALUATION; SKIN; BIOLOGICAL RADIATION EFFECTS; FAR ULTRAVIOLET RADIATION; MICE; NEOPLASMS; TUMOR PROMOTERS; UREA; AMIDES; ANIMALS; BIOLOGICAL EFFECTS; BODY; CARBONIC ACID DERIVATIVES; DISEASES; ELECTROMAGNETIC RADIATION; MAMMALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PATHOGENESIS; PROMOTERS; RADIATION EFFECTS; RADIATIONS; RODENTS; ULTRAVIOLET RADIATION; VERTEBRATES 560152* -- Radiation Effects on Animals-- Animals

Citation Formats

Epstein, J.H. Stimulation of ultraviolet-induced carcinogenesis by 1,3-bis(2-chloroethyl)-1-nitrosourea. United States: N. p., 1979. Web.
Epstein, J.H. Stimulation of ultraviolet-induced carcinogenesis by 1,3-bis(2-chloroethyl)-1-nitrosourea. United States.
Epstein, J.H. Thu . "Stimulation of ultraviolet-induced carcinogenesis by 1,3-bis(2-chloroethyl)-1-nitrosourea". United States.
@article{osti_6739195,
title = {Stimulation of ultraviolet-induced carcinogenesis by 1,3-bis(2-chloroethyl)-1-nitrosourea},
author = {Epstein, J.H.},
abstractNote = {The influence of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on ultraviolet-induced carcinogenesis was examined in hairless mouse skin in vivo. Noncarcinogenic amounts of topically applied BCNU and carcinogenic levels of UVB energy were utilized in the study. The applications of BCNU significantly accelerated the appearance and growth of the cutaneous tumors in this study. Thus, the BCNU acted as either a promoting or a cocarcinogenic agent for ultraviolet-induced cancer formation. Although the mechanism of this effect has not been established, avoidance of extensive sun exposure would probably be prudent when topical BCNU is being utilized therapeutically.},
doi = {},
journal = {Cancer Res.; (United States)},
number = ,
volume = 39:2,
place = {United States},
year = {1979},
month = {2}
}