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Title: Effect of respiratory infection on the elution of benzo(a)pyrene from carbon particles in the respiratory tract of mice

Abstract

The effect of respiratory infection by PR8 influenza virus on the elution of benzo(a)pyrene (BaP) from carbon particles in the respiratory tract of mice was studied. In mice, this virus produces, among other phenomena, a proteinaceous effusion and mixed cellular exudate in the alveolar parenchyma during the acute phase of infection. If BaP-coated carbon particles are introduced into the respiratory tract during the acute stage of infection, the rate of BaP elution from the carbon particles is increased. When BaP-coated carbon particles were instilled in the respiratory tract either 1 wk before or 2 wk after the acute stage of infection, the BaP elution rate from carbon particles was similar to that in uninfected animals.

Authors:
Publication Date:
Research Org.:
Oak Ridge National Lab., TN
OSTI Identifier:
6736150
Alternate Identifier(s):
OSTI ID: 6736150
Resource Type:
Journal Article
Journal Name:
J. Toxicol. Environ. Health; (United States)
Additional Journal Information:
Journal Volume: 3:5-6
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; BENZOPYRENE; LUNG CLEARANCE; INFECTIOUS DISEASES; RESPONSE MODIFYING FACTORS; AIR POLLUTION; CARBON; ELUTRIATION; INFLUENZA; INTRATRACHEAL ADMINISTRATION; MICE; PARTICLES; RESPIRATORY SYSTEM; TIME DEPENDENCE; VIRUSES; ANIMALS; AROMATICS; CLEARANCE; CONDENSED AROMATICS; DISEASES; ELEMENTS; EXCRETION; HYDROCARBONS; MAMMALS; MICROORGANISMS; NONMETALS; ORGANIC COMPOUNDS; PARASITES; POLLUTION; RODENTS; SEPARATION PROCESSES; VERTEBRATES 560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987); 550700 -- Microbiology

Citation Formats

Creasia, D.A. Effect of respiratory infection on the elution of benzo(a)pyrene from carbon particles in the respiratory tract of mice. United States: N. p., 1977. Web. doi:10.1080/15287397709529634.
Creasia, D.A. Effect of respiratory infection on the elution of benzo(a)pyrene from carbon particles in the respiratory tract of mice. United States. doi:10.1080/15287397709529634.
Creasia, D.A. Thu . "Effect of respiratory infection on the elution of benzo(a)pyrene from carbon particles in the respiratory tract of mice". United States. doi:10.1080/15287397709529634.
@article{osti_6736150,
title = {Effect of respiratory infection on the elution of benzo(a)pyrene from carbon particles in the respiratory tract of mice},
author = {Creasia, D.A.},
abstractNote = {The effect of respiratory infection by PR8 influenza virus on the elution of benzo(a)pyrene (BaP) from carbon particles in the respiratory tract of mice was studied. In mice, this virus produces, among other phenomena, a proteinaceous effusion and mixed cellular exudate in the alveolar parenchyma during the acute phase of infection. If BaP-coated carbon particles are introduced into the respiratory tract during the acute stage of infection, the rate of BaP elution from the carbon particles is increased. When BaP-coated carbon particles were instilled in the respiratory tract either 1 wk before or 2 wk after the acute stage of infection, the BaP elution rate from carbon particles was similar to that in uninfected animals.},
doi = {10.1080/15287397709529634},
journal = {J. Toxicol. Environ. Health; (United States)},
number = ,
volume = 3:5-6,
place = {United States},
year = {1977},
month = {12}
}