Amino acid analogs for tumor imaging
The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of 1-amino-cycloalkyl-1-carboxylic acids, namely, their rapid uptake and prolonged retention in tumors with the properties of halogen substituents, including certain useful halogen isotopes including fluorine-18, iodine-123, iodine-125, iodine-131, bromine-75, bromine-76, bromine-77 and bromine-82. In one aspect, the invention features amino acid compounds that have a high specificity for target sites when administered to a subject in vivo. Preferred amino acid compounds show a target to non-target ratio of at least 5:1, are stable in vivo and substantially localized to target within 1 hour after administration. An especially preferred amino acid compound is [{sup 18}F]-1-amino-3-fluorocyclobutane-1-carboxylic acid (FACBC). In another aspect, the invention features pharmaceutical compositions comprised of an {alpha}-amino acid moiety attached to either a four, five, or a six member carbon-chain ring. In addition, the invention features analogs of {alpha}-aminoisobutyric acid.
- Research Organization:
- Emory Univ., Atlanta, GA (United States)
- Sponsoring Organization:
- USDOE, Washington, DC (United States)
- DOE Contract Number:
- FG05-93ER61737
- Assignee:
- Emory Univ., Atlanta, GA (United States)
- Patent Number(s):
- US 5,808,146/A/
- Application Number:
- PAN: 8-554,906; TRN: 99:001108
- OSTI ID:
- 672678
- Resource Relation:
- Other Information: PBD: 15 Sep 1998
- Country of Publication:
- United States
- Language:
- English
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Amino acid analogs for tumor imaging
Amino acid analogs for tumor imaging