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Title: Mutant E. coli strain with increased succinic acid production

Abstract

A method for isolating succinic acid producing bacteria is provided comprising increasing the biomass of an organism which lacks the ability to catabolize pyruvate, and then subjecting the biomass to glucose-rich medium in an anaerobic environment to enable pyruvate-catabolizing mutants to grow. The invention also provides for a mutant that produces high amounts of succinic acid, which as been derived from a parent which lacked the genes for pyruvate formate lyase and lactate dehydrogenase, and which belongs to the E.coli Group of Bacteria. 2 figs.

Inventors:
; ;
Publication Date:
Research Org.:
Univ. of Chicago, IL (United States)
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
672567
Patent Number(s):
US 5,770,435/A/
Application Number:
PAN: 8-556,805
Assignee:
Univ. of Chicago, IL (United States)
DOE Contract Number:  
W-31109-ENG-38
Resource Type:
Patent
Resource Relation:
Other Information: PBD: 23 Jun 1998
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; ESCHERICHIA COLI; SUCCINIC ACID; BIOSYNTHESIS; MUTANTS; PYRUVIC ACID; GENES; LYASES; OXIDOREDUCTASES

Citation Formats

Donnelly, M, Millard, C S, and Stols, L. Mutant E. coli strain with increased succinic acid production. United States: N. p., 1998. Web.
Donnelly, M, Millard, C S, & Stols, L. Mutant E. coli strain with increased succinic acid production. United States.
Donnelly, M, Millard, C S, and Stols, L. 1998. "Mutant E. coli strain with increased succinic acid production". United States.
@article{osti_672567,
title = {Mutant E. coli strain with increased succinic acid production},
author = {Donnelly, M and Millard, C S and Stols, L},
abstractNote = {A method for isolating succinic acid producing bacteria is provided comprising increasing the biomass of an organism which lacks the ability to catabolize pyruvate, and then subjecting the biomass to glucose-rich medium in an anaerobic environment to enable pyruvate-catabolizing mutants to grow. The invention also provides for a mutant that produces high amounts of succinic acid, which as been derived from a parent which lacked the genes for pyruvate formate lyase and lactate dehydrogenase, and which belongs to the E.coli Group of Bacteria. 2 figs.},
doi = {},
url = {https://www.osti.gov/biblio/672567}, journal = {},
number = ,
volume = ,
place = {United States},
year = {1998},
month = {6}
}