Kinetics of intraepithelial lymphocytes in the small intestine of thymus-deprived mice and antigen-deprived mice

Journal Article · Sat May 01 00:00:00 EDT 1976 · Anat. Rec.; (United States)

DOI:https://doi.org/10.1002/ar.1091850110· OSTI ID:6725362

Roepke, C; Everett, N B

The kinetics of lymphoid cells within the epithelium of the small gut has been studied in various thymus-deprived mice and in antigen-deprived mice by the use of /sup 3/H-thymidine injections and radioautography. In thymus-deprived mice--including adult thymectomized, thymectomized and irradiated, neonatally thymectomized, and nude mice--and in germ-free mice decreased numbers of intraepithelial lymphocytes (IL) were found. On the other hand, the radioautographic results indicated that the remaining IL populations included both newly formed and long-lived lymphoid cells in the same percentages as found in sham-operated controls and normal mice. It is concluded that although the presence of the thymus and the antigen content of the gut is of importance to the maintenance of the numbers of cells in the lymphoid populations of the intestinal wall, the basic kinetics of these cell populations are preserved in deprived mice.

• Research Organization: Univ., Copenhagen
• OSTI ID: 6725362
• Journal Information: Anat. Rec.; (United States), Vol. 185:1
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANTIGENS
BIOLOGICAL EFFECTS
LYMPHOCYTES
KINETICS
THYMECTOMY
ABUNDANCE
AUTORADIOGRAPHY
EPITHELIUM
MICE
SMALL INTESTINE
THYMUS
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
GASTROINTESTINAL TRACT
INTESTINES
LEUKOCYTES
LYMPHATIC SYSTEM
MAMMALS
MEDICINE
ORGANS
RODENTS
SOMATIC CELLS
SURGERY
TISSUES
VERTEBRATES
550300* - Cytology