Solution and solid-state characterization of europium and gadolinium Schiff base complexes and assessment of their potential as contrast agents in magnetic resonance imaging
- Los Alamos National Lab., NM (USA)
Two lanthanide Schiff base macrocyclic complexes, LnAM(OAc){sub 2}Cl{center dot}4H{sub 2}O (Ln = Eu, Gd; HAM - HexaAzaMacrocycle = C{sub 22}H{sub 26}N{sub 6}), have been characterized in view of the potential of the Gd complex as a magnetic resonance imaging (MRI) contrast agent. The relaxivity of GdHAM(OAc){sub 2}Cl was measured at 300 and 20 MHz and is as high as that for the gadolinium aquo ion. The number of coordinated waters, q, was measured by comparison of the luminescent lifetimes of EuHAM(OAc){sub 2}Cl in H{sub 2}O and D{sub 2}O and found to be between three and four. The complex GdHAM(OAc){sub 2}Cl{center dot}4H{sub 2}O was characterized by single-crystal X-ray diffraction. The complex crystallizes in space group P{bar 1} with Z = 2, a = 10.032 (2) {angstrom}, b = 12.765 (2) {angstrom}, c = 13.668 (3) {angstrom}, {alpha} = 69.190{degree} (9){degree}, {beta} = 72.405{degree} (9){degree}, and {gamma} = 74.07{degree} (1){degree}.
- OSTI ID:
- 6725175
- Journal Information:
- Journal of the American Chemical Society; (USA), Vol. 111:19; ISSN 0002-7863
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
62 RADIOLOGY AND NUCLEAR MEDICINE
BIOLOGICAL MARKERS
GADOLINIUM COMPLEXES
CRYSTAL STRUCTURE
CALCULATION METHODS
DATA ANALYSIS
EUROPIUM COMPLEXES
EXPERIMENTAL DATA
MAGNETIC RESONANCE
MEASURING INSTRUMENTS
MEASURING METHODS
SCHIFF BASES
COMPLEXES
DATA
IMINES
INFORMATION
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RARE EARTH COMPLEXES
RESONANCE
360104* - Metals & Alloys- Physical Properties
360102 - Metals & Alloys- Structure & Phase Studies
400200 - Inorganic
Organic
& Physical Chemistry
550600 - Medicine