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Title: Effects of dose and of partial body ionizing radiation on taste aversion learning in rats with lesions of the area postrema

Abstract

The effect of area postrema lesions on the acquisition of a conditioned taste aversion following partial body exposure to ionizing radiation was investigated in rats exposed to head-only irradiation at 100, 200 and 300 rad or to body-only irradiation at 100 and 200 rad. Following head-only irradiation area postrema lesions produced a significant attenuation of the radiation-induced taste aversion at all dose levels, although the rats still showed a significant reduction in sucrose preference. Following body-only exposure, area postrema lesions completely disrupted the acquisition of the conditioned taste aversion. The results are interpreted as indicating that: (a) the acquisition of a conditioned taste aversion following body-only exposure is mediated by the area postrema; and (b) taste aversion learning following radiation exposure to the head-only is mediated by both the area postrema and a mechanism which is independent of the area postrema.

Authors:
; ;
Publication Date:
Research Org.:
Behavioral Sciences Department, Armed Forces Radiobiology Research Institute, Bethesda, MD
OSTI Identifier:
6722917
Resource Type:
Journal Article
Journal Name:
Physiol. Behav.; (United States)
Additional Journal Information:
Journal Volume: 32:1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; BRAIN; BIOLOGICAL RADIATION EFFECTS; DOSE-RESPONSE RELATIONSHIPS; IONIZING RADIATIONS; LEARNING; RATS; TASTE BUDS; ANIMALS; BIOLOGICAL EFFECTS; BODY; CENTRAL NERVOUS SYSTEM; MAMMALS; NERVOUS SYSTEM; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; SENSE ORGANS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals; 550100 - Behavioral Biology

Citation Formats

Rabin, B M, Hunt, W A, and Lee, J. Effects of dose and of partial body ionizing radiation on taste aversion learning in rats with lesions of the area postrema. United States: N. p., 1984. Web. doi:10.1016/0031-9384(84)90081-7.
Rabin, B M, Hunt, W A, & Lee, J. Effects of dose and of partial body ionizing radiation on taste aversion learning in rats with lesions of the area postrema. United States. https://doi.org/10.1016/0031-9384(84)90081-7
Rabin, B M, Hunt, W A, and Lee, J. 1984. "Effects of dose and of partial body ionizing radiation on taste aversion learning in rats with lesions of the area postrema". United States. https://doi.org/10.1016/0031-9384(84)90081-7.
@article{osti_6722917,
title = {Effects of dose and of partial body ionizing radiation on taste aversion learning in rats with lesions of the area postrema},
author = {Rabin, B M and Hunt, W A and Lee, J},
abstractNote = {The effect of area postrema lesions on the acquisition of a conditioned taste aversion following partial body exposure to ionizing radiation was investigated in rats exposed to head-only irradiation at 100, 200 and 300 rad or to body-only irradiation at 100 and 200 rad. Following head-only irradiation area postrema lesions produced a significant attenuation of the radiation-induced taste aversion at all dose levels, although the rats still showed a significant reduction in sucrose preference. Following body-only exposure, area postrema lesions completely disrupted the acquisition of the conditioned taste aversion. The results are interpreted as indicating that: (a) the acquisition of a conditioned taste aversion following body-only exposure is mediated by the area postrema; and (b) taste aversion learning following radiation exposure to the head-only is mediated by both the area postrema and a mechanism which is independent of the area postrema.},
doi = {10.1016/0031-9384(84)90081-7},
url = {https://www.osti.gov/biblio/6722917}, journal = {Physiol. Behav.; (United States)},
number = ,
volume = 32:1,
place = {United States},
year = {Sun Jan 01 00:00:00 EST 1984},
month = {Sun Jan 01 00:00:00 EST 1984}
}