Indium 111-labeled granulocyte scan in the diagnosis and management of acute inflammatory bowel disease

Journal Article · Fri Jun 01 00:00:00 EDT 1990 · Diseases of the Colon and Rectum; (USA)

DOI:https://doi.org/10.1007/BF02052137· OSTI ID:6717363

Nelson, R L; Subramanian, K; Gasparaitis, A; Abcarian, H; Pavel, D G ^[1]

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1. Univ. of Illinois College of Medicine, Chicago (USA)

The indium 111 granulocyte scan was used to evaluate 39 individuals known to have or suspected of having inflammatory bowel disease. Twenty-three of these individuals had positive scans and 16 had negative scans. Eighty-seven confirmatory studies, which consisted of barium radiography, endoscopy, operative findings, and histopathology, were performed in 37 of these individuals. The remaining two negative scans corroborated only by clinical course, CBC, and erythrocyte sedimentation rate. In addition, 10 follow-up scans were performed in six of the 39 patients to monitor therapy or investigate a change in symptoms. As an anatomic indicator of acute granulocytic infiltration of the intestinal lamina propria and crypts, the authors found that this scan had a 97 percent rate of sensitivity and 100 percent specificity. Specific indications for the use of the indium 111-labeled granulocyte scan are described. For the authors, in general, this test has become a vital adjunct to endoscopy and radiography in the diagnosis and management of patients with symptoms of inflammatory bowel disease.

• OSTI ID: 6717363
• Journal Information: Diseases of the Colon and Rectum; (USA), Vol. 33:6; ISSN 0012-3706
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
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LABELLING
RADIOISOTOPE SCANNING
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ANIMALS
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MAMMALS
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NUCLEI
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