Chemical protection against gastrointestinal radiation injury in mice by WR 2822, WR 2823, or WR 109342 after 4 MeV x ray or fission neutron irradiation
Three compounds were tested for their radioprotective properties against the effects of 4 MeV X rays or fission neutron irradiation. The endpoints tested were lethality, intestinal crypt survival, and DNA synthesizing cellularity. Two of the compounds tested; S-2(4-aminobutylamino) ethylphosphorothioc acid (WR 2822) and the aminopentylamino derivative (WR 109342). All drugs were administered via intraperitoneal injections at their approximately maximum tolerated dose. WR 2822 was shown to have a slight protective effect against X rays and neutrons. The dose modification factor (DMF) for gastrointestinal death (LD/sub 50(6)/) was 1.23 for X rays and 1.51 for neutrons. The assay for intestinal crypt survival produced DMF's of 1.44 (X rays) and 1.4 (neutrons). WR 2823 also showed a protective action in these assays. The DMF for LD/sub 50(6)/ was 1.32 (X rays) and 1.42 (neutrons). WR 109342 was found to be extremely toxic and had no significant protective effects. All three drugs were more toxic and demonstrated less protection in most of these assays than the benchmark radioprotective agent WR 2721, although WR 2822 protected against lethal effects of fission neutrons almost as well as WR 2721. Both WR 2822 and WR 2823 produced greater protection in the crypt survival assays for fission neutron irradiation than WR 2721.
- Research Organization:
- Univ. of Louisville, KY
- OSTI ID:
- 6713634
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 8:3/4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
DNA
BIOLOGICAL RADIATION EFFECTS
GASTROINTESTINAL TRACT
RADIOPROTECTIVE SUBSTANCES
LETHAL DOSES
RADIOSENSITIVITY EFFECTS
BIOSYNTHESIS
CRYPT CELLS
FISSION NEUTRONS
INTRAPERITONEAL INJECTION
MEV RANGE 01-10
MICE
THIOIC ACIDS
THIOLS
X RADIATION
ANIMAL CELLS
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
DIGESTIVE SYSTEM
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
ENERGY RANGE
FERMIONS
HADRONS
INJECTION
INTAKE
IONIZING RADIATIONS
MAMMALS
MEV RANGE
NEUTRONS
NUCLEIC ACIDS
NUCLEONS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
SYNTHESIS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals