Gastric emptying and intragastric distribution of lipids in man. A new scintigraphic method of study

Journal Article · Sun Aug 01 00:00:00 EDT 1982 · Dig. Dis. Sci.; (United States)

DOI:https://doi.org/10.1007/BF01393765· OSTI ID:6711104

Jian, R; Vigneron, N; Najean, Y; Bernier, J J

We measured gastric emptying of fat and water from a solid-liquid meal in healthy volunteers using a tubeless scintigraphic method. /sup 75/Se glycerol triether, incorporated in butter, was the lipid-phase marker, and /sup 99m/Tcm, ingested with 250 ml water, the non-lipid phase marker. In seven of these subjects we also measured the gastric emptying of solids and liquids with /sup 99m/Tc bound to cooked egg whites as the solid-phase marker and /sup 111/In ingested with 250 ml water as the marker of the solid and aqueous phases. Emptying and intragastric repartition of each marker were measured by detection of radioactivity changes over the abdominal area using a gamma-camera. The stability and the specificity of the labeling was checked for each marker. Mean gastric emptying rate (expressed as percentage ingested marker emptied per hr) of lipids (17.4 +/- 2.4) was much lower than that of the rest of the meal (34.2 +/- 1.8) and slightly, but significantly, lower than that of solids (22.8 +/- 1.8). An intragastric layering of fat above nonlipids was observed only after the first postprandial hour and remained moderate. Thus, lipids are emptied more slowly than any other component of an ordinary meal, and this is not due only to layering of fat above water.

• Research Organization: Research Unit on Pathophysiology of Digestion, Hospital Saint-Lazare, Paris, France
• OSTI ID: 6711104
• Journal Information: Dig. Dis. Sci.; (United States), Vol. 27:8
• Country of Publication: United States
• Language: English

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