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Title: Spectral dependencies of killing, mutation, and transformation in mammalian cells and their relevance to hazards caused by solar ultraviolet radiation

Abstract

Using germicidal lamps and Westinghouse sunlamps with and without filtration, the effectiveness of ultraviolet and near-ultraviolet light in inducing moleculear and cellular changes was measured. From the results of the study, it is inferred that increasing intensities of short-wavelength ultraviolet light, as would be expected from reductions in stratospheric ozone around the earth, would result in smaller increases in biological action (e.g., skin cancer, compared to current levels of action than would be predicted from an action spectrum completely correspnding to that of a pyrimidine dimer induction spectrum in DNA). (JMT)

Authors:
; ; ; ;
Publication Date:
Research Org.:
Argonne National Lab., IL
OSTI Identifier:
6705463
DOE Contract Number:  
W-31-109-ENG-38
Resource Type:
Journal Article
Journal Name:
Cancer Res.; (United States)
Additional Journal Information:
Journal Volume: 41
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ANIMAL CELLS; BIOLOGICAL RADIATION EFFECTS; CELL KILLING; RADIOINDUCTION; DNA; MUTATIONS; ONCOGENIC TRANSFORMATIONS; ABSORPTION SPECTRA; DIMERS; NEAR ULTRAVIOLET RADIATION; PYRIMIDINES; SPECTRAL RESPONSE; ULTRAVIOLET RADIATION; AZINES; BIOLOGICAL EFFECTS; ELECTROMAGNETIC RADIATION; HETEROCYCLIC COMPOUNDS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIATION EFFECTS; RADIATIONS; SPECTRA; 560121* - Radiation Effects on Cells- External Source- (-1987)

Citation Formats

Suzuki, F, Han, A, Lankas, G R, Utsumi, H, and Elkind, M M. Spectral dependencies of killing, mutation, and transformation in mammalian cells and their relevance to hazards caused by solar ultraviolet radiation. United States: N. p., 1981. Web.
Suzuki, F, Han, A, Lankas, G R, Utsumi, H, & Elkind, M M. Spectral dependencies of killing, mutation, and transformation in mammalian cells and their relevance to hazards caused by solar ultraviolet radiation. United States.
Suzuki, F, Han, A, Lankas, G R, Utsumi, H, and Elkind, M M. 1981. "Spectral dependencies of killing, mutation, and transformation in mammalian cells and their relevance to hazards caused by solar ultraviolet radiation". United States.
@article{osti_6705463,
title = {Spectral dependencies of killing, mutation, and transformation in mammalian cells and their relevance to hazards caused by solar ultraviolet radiation},
author = {Suzuki, F and Han, A and Lankas, G R and Utsumi, H and Elkind, M M},
abstractNote = {Using germicidal lamps and Westinghouse sunlamps with and without filtration, the effectiveness of ultraviolet and near-ultraviolet light in inducing moleculear and cellular changes was measured. From the results of the study, it is inferred that increasing intensities of short-wavelength ultraviolet light, as would be expected from reductions in stratospheric ozone around the earth, would result in smaller increases in biological action (e.g., skin cancer, compared to current levels of action than would be predicted from an action spectrum completely correspnding to that of a pyrimidine dimer induction spectrum in DNA). (JMT)},
doi = {},
url = {https://www.osti.gov/biblio/6705463}, journal = {Cancer Res.; (United States)},
number = ,
volume = 41,
place = {United States},
year = {Tue Dec 01 00:00:00 EST 1981},
month = {Tue Dec 01 00:00:00 EST 1981}
}