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Title: Effect of tropicamide on ocular blood flow in the rabbit

Abstract

Intracardiac injection of 15 microspheres labeled with /sup 85/Sr (strontium) and /sup 141/Ce (cerium) were used to determine ocular blood flow in seven rabbits before and 25 min after bilateral application of tropicamide to the cornea. By using two different isotopes distinguishable under gammaspectrometry, each animal served as its own control. After administration of two drops of 1% tropicamide, no significant difference in blood flow between treated and untreated eyes was observed.

Authors:
; ;
Publication Date:
Research Org.:
Southern California College of Optometry, Fullerton
OSTI Identifier:
6704985
Alternate Identifier(s):
OSTI ID: 6704985
Resource Type:
Journal Article
Resource Relation:
Journal Name: Am. J. Optom. Physiol. Opt.; (United States); Journal Volume: 59:5
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; CERIUM 141; ISOTOPE APPLICATIONS; ORGANIC NITROGEN COMPOUNDS; BIOLOGICAL EFFECTS; STRONTIUM 85; BLOOD FLOW; EYES; MICROSPHERES; OPHTHALMOLOGY; RABBITS; ALKALINE EARTH ISOTOPES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; BODY AREAS; CERIUM ISOTOPES; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; FACE; HEAD; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MEDICINE; NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIOISOTOPES; RARE EARTH ISOTOPES; RARE EARTH NUCLEI; SENSE ORGANS; STRONTIUM ISOTOPES; VERTEBRATES 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics; 551001 -- Physiological Systems-- Tracer Techniques

Citation Formats

Delgado, D., Michel, P., and Jaanus, S.D.. Effect of tropicamide on ocular blood flow in the rabbit. United States: N. p., 1982. Web. doi:10.1097/00006324-198205000-00008.
Delgado, D., Michel, P., & Jaanus, S.D.. Effect of tropicamide on ocular blood flow in the rabbit. United States. doi:10.1097/00006324-198205000-00008.
Delgado, D., Michel, P., and Jaanus, S.D.. Sat . "Effect of tropicamide on ocular blood flow in the rabbit". United States. doi:10.1097/00006324-198205000-00008.
@article{osti_6704985,
title = {Effect of tropicamide on ocular blood flow in the rabbit},
author = {Delgado, D. and Michel, P. and Jaanus, S.D.},
abstractNote = {Intracardiac injection of 15 microspheres labeled with /sup 85/Sr (strontium) and /sup 141/Ce (cerium) were used to determine ocular blood flow in seven rabbits before and 25 min after bilateral application of tropicamide to the cornea. By using two different isotopes distinguishable under gammaspectrometry, each animal served as its own control. After administration of two drops of 1% tropicamide, no significant difference in blood flow between treated and untreated eyes was observed.},
doi = {10.1097/00006324-198205000-00008},
journal = {Am. J. Optom. Physiol. Opt.; (United States)},
number = ,
volume = 59:5,
place = {United States},
year = {Sat May 01 00:00:00 EDT 1982},
month = {Sat May 01 00:00:00 EDT 1982}
}
  • A survey of the rabbit's normal microcirculation of blood flow volume in the endometrium and myometrium with or without a copper intrauterine device (IUD) was made. It was found through statistical analyses that the IUD stimulated the endometrium so that microcirculation of blood flow volume in the endometrium increased significantly, but it did not change the microcirculation of blood flow volume in the myometrium and in the opposite uterus.
  • A survey of the rabbit's normal microcirculation of blood flow volume in the endometrium and myometrium with or without a copper intrauterine device (IUD) was made. It was found through statistical analyses that the IUD stimulated the endometrium so that microcirculation of blood flow volume in the endometrium increased significantly, but it did not change the microcirculation of blood flow volume in the myometrium and in the opposite uterus.
  • 125I-Albumin permeation and blood flow (assessed with 15 micron, 85Sr-labelled microspheres) were determined in the retina, choroid, anterior uvea, and brain of male Sprague-Dawley rats fed diets containing 50% dextrin (control) or 50% galactose. Blood flow was increased in the retina, choroid, and anterior uvea but not in the brain of rats fed galactose for 3 weeks and 3 months versus controls, and was normalized by sorbinil (an inhibitor of aldose reductase) in the 3-week group. After 8 months of galactose feeding, blood flow was reduced to normal levels in the retina and was slightly below normal in the choroid;more » blood flow remained elevated in the anterior uvea but was significantly lower than that observed at 3 weeks and at 3 months. In rats fed galactose for 8 months, sorbinil completely normalized blood flow in the choroid, and decreased, but did not normalize, blood flow in the anterior uvea. 125I-Albumin permeation was increased in the retina, choroid, and anterior uvea of rats fed 50% galactose for 3 weeks, 3 months, and 8 months versus controls, but was unchanged in the brain. Sorbinil normalized 125I-albumin permeation in all three ocular tissues in 8-month galactose-fed rats. Polyol levels were increased significantly in all three ocular tissues of 3-week galactose-fed rats; sorbinil markedly decreased, but did not normalize, polyol levels in all three tissues.« less