(/sup 11/C)clorgyline and (/sup 11/C)-L-deprenyl and their use in measuring functional monoamine oxidase activity in the brain using positron emission tomography
This invention involves a new strategy for imaging the activity of the enzyme monoamine oxidase in the living body by using /sup 11/C-labeled enzyme inhibitors which bind irreversibly to an enzyme as a result of catalysis. By using positron emission tomography to image the distribution of radioactivity produced by the body penetrating radiation emitted by carbon-11, a map of functionally active monoamine oxidase activity is obtained. Clorgyline and L-deprenyl are suicide enzyme inhibitors and irreversibly inhibit monoamine oxidase. When these inhibitors are labeled with carbon-11 they provide selective probes for monoamine oxidase localization and reactivity in vivo using positron emission tomography. 2 figs.
- Research Organization:
- Brookhaven National Lab., Upton, NY (USA)
- DOE Contract Number:
- AC02-76CH00016
- Assignee:
- Dept. of Energy
- Patent Number(s):
- None
- Application Number:
- ON: DE87007235
- OSTI ID:
- 6701426
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
AMINE OXIDASES
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BABOONS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
BRAIN
CARBON 11
CARBON ISOTOPES
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CHEMICAL PREPARATION
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
EMISSION COMPUTED TOMOGRAPHY
ENZYME INHIBITORS
ENZYMES
EVEN-ODD NUCLEI
GLANDS
HEART
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LIGHT NUCLEI
LIVER
LUNGS
MAMMALS
MATERIALS
MICE
MINUTES LIVING RADIOISOTOPES
MONKEYS
NERVOUS SYSTEM
NUCLEI
ORGANS
OXIDOREDUCTASES
POSITRON COMPUTED TOMOGRAPHY
PRIMATES
RADIOISOTOPES
RADIOPHARMACEUTICALS
RESPIRATORY SYSTEM
RODENTS
SYMPATHOMIMETICS
SYNTHESIS
TISSUE DISTRIBUTION
TOMOGRAPHY
VERTEBRATES