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Title: Clinical committee report: Recommendation for further clinical trials-patient studies

Abstract

The Cf-252 (Cf) neutron brachytherapy (NT) trials should continue to explore the feasibility of Cf-NT treatment of a variety of bulky human cancers. Results hitherto from the USA (Lexington), Japan, USSR, and England justify trials on a research basis. The term ''bulky'' is imprecise and in future studies should be specified by measurement. U.S. Department of Energy and other suppliers need to be advised to fabricate Cf-252 sources in more appropriate sizes, strengths and configurations for clinical therapy. Study of facility design and development should continue with special attention to: 1) treatment centers, 2) afterloading devices, 3) automated/robotics and other specialized equipment for handling Cf-252, 4) shields and shielding material, 5) controlled duration treatments, 6) necessary specialized equipment for conducting Cf-NT trials and 7) safety for personnel. In addition to the aforementioned, the report makes recommendations in several other areas such as doses and schedules, randomized trials, and records.

Authors:
Publication Date:
Research Org.:
Emeritus Consultant, Churchill Hospital, Oxford
OSTI Identifier:
6698536
Resource Type:
Journal Article
Journal Name:
Nucl. Sci. Appl.; (United States)
Additional Journal Information:
Journal Volume: 2:3
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CALIFORNIUM 252; THERAPEUTIC USES; NEOPLASMS; NEUTRON THERAPY; FEASIBILITY STUDIES; HUMAN POPULATIONS; JAPAN; KENTUCKY; PERFORMANCE TESTING; RADIATION DOSES; RESEARCH PROGRAMS; UNITED KINGDOM; USSR; ACTINIDE ISOTOPES; ACTINIDE NUCLEI; ALPHA DECAY RADIOISOTOPES; ASIA; CALIFORNIUM ISOTOPES; DISEASES; DOSES; EASTERN EUROPE; EUROPE; EVEN-EVEN NUCLEI; FEDERAL REGION IV; HEAVY NUCLEI; ISOTOPES; MEDICINE; NORTH AMERICA; NUCLEAR MEDICINE; NUCLEI; POPULATIONS; RADIOISOTOPES; RADIOLOGY; RADIOTHERAPY; TESTING; THERAPY; USA; USES; WESTERN EUROPE; YEARS LIVING RADIOISOTOPES; 550603* - Medicine- External Radiation in Therapy- (1980-); 550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)

Citation Formats

Ellis, F. Clinical committee report: Recommendation for further clinical trials-patient studies. United States: N. p., 1986. Web.
Ellis, F. Clinical committee report: Recommendation for further clinical trials-patient studies. United States.
Ellis, F. 1986. "Clinical committee report: Recommendation for further clinical trials-patient studies". United States.
@article{osti_6698536,
title = {Clinical committee report: Recommendation for further clinical trials-patient studies},
author = {Ellis, F},
abstractNote = {The Cf-252 (Cf) neutron brachytherapy (NT) trials should continue to explore the feasibility of Cf-NT treatment of a variety of bulky human cancers. Results hitherto from the USA (Lexington), Japan, USSR, and England justify trials on a research basis. The term ''bulky'' is imprecise and in future studies should be specified by measurement. U.S. Department of Energy and other suppliers need to be advised to fabricate Cf-252 sources in more appropriate sizes, strengths and configurations for clinical therapy. Study of facility design and development should continue with special attention to: 1) treatment centers, 2) afterloading devices, 3) automated/robotics and other specialized equipment for handling Cf-252, 4) shields and shielding material, 5) controlled duration treatments, 6) necessary specialized equipment for conducting Cf-NT trials and 7) safety for personnel. In addition to the aforementioned, the report makes recommendations in several other areas such as doses and schedules, randomized trials, and records.},
doi = {},
url = {https://www.osti.gov/biblio/6698536}, journal = {Nucl. Sci. Appl.; (United States)},
number = ,
volume = 2:3,
place = {United States},
year = {Wed Jan 01 00:00:00 EST 1986},
month = {Wed Jan 01 00:00:00 EST 1986}
}