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Title: Late effects of radiation on the lumbar spinal cord of guinea pigs: Re-treatment tolerance

Abstract

Using a guinea pig model of lumbar myelopathy, various factors affecting the tolerance of spinal cord to irradiation were assessed: (a) extent of initial injury; (b) time interval between priming and test doses; and (c) animal age at the time of initial radiation treatment. A 3 cm section of lumbar spinal cord of guinea pigs was irradiated with fractionated doses of 4.5 Gy gamma rays given as 9 fractions per week. Guinea pigs were primed with 9 x 4.5 Gy in 7 days which is 60% of the ED[sub 50] for a continuous course of treatment. After 28 or 40 weeks, animal were retreated with 6-14 fractions of 4.5 Gy. Animals were observed for 2 years following the priming dose and both the incidence and latency of myelopathy recorded. Young adult guinea pigs (8 wk old) showed both a decreased radiation tolerance and latency compared to old individuals (40 wk old). At 28 or 40 wk after 9 x 4.5 Gy, only about 8% of the initial injury was remembered in young adult guinea pigs. The amount of residual injury was dependent on the initial damage as a proportion of the tolerance dose. The spinal cord shows a greater capacitymore » for long-term recovery than generally appreciated and re-treatment doses clinically prescribed may be lower than necessary. 8 refs., 3 figs., 2 tabs.« less

Authors:
 [1]; ;  [2]
  1. Univ. of Texas M.D. Anderson Cancer Center, Houston, TX (United States)
  2. Univ. of California, Los Angeles, CA (United States)
Publication Date:
OSTI Identifier:
6694866
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics; (United States)
Additional Journal Information:
Journal Volume: 26:4; Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; RADIOTHERAPY; SIDE EFFECTS; SPINAL CORD; RADIATION INJURIES; FRACTIONATED IRRADIATION; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; CENTRAL NERVOUS SYSTEM; INJURIES; IRRADIATION; MEDICINE; NERVOUS SYSTEM; NUCLEAR MEDICINE; RADIATION EFFECTS; RADIOLOGY; THERAPY; 560152* - Radiation Effects on Animals- Animals

Citation Formats

Mason, K A, Withers, H R, and Chiang, Chi-Shiun. Late effects of radiation on the lumbar spinal cord of guinea pigs: Re-treatment tolerance. United States: N. p., 1993. Web. doi:10.1016/0360-3016(93)90282-Z.
Mason, K A, Withers, H R, & Chiang, Chi-Shiun. Late effects of radiation on the lumbar spinal cord of guinea pigs: Re-treatment tolerance. United States. doi:10.1016/0360-3016(93)90282-Z.
Mason, K A, Withers, H R, and Chiang, Chi-Shiun. Thu . "Late effects of radiation on the lumbar spinal cord of guinea pigs: Re-treatment tolerance". United States. doi:10.1016/0360-3016(93)90282-Z.
@article{osti_6694866,
title = {Late effects of radiation on the lumbar spinal cord of guinea pigs: Re-treatment tolerance},
author = {Mason, K A and Withers, H R and Chiang, Chi-Shiun},
abstractNote = {Using a guinea pig model of lumbar myelopathy, various factors affecting the tolerance of spinal cord to irradiation were assessed: (a) extent of initial injury; (b) time interval between priming and test doses; and (c) animal age at the time of initial radiation treatment. A 3 cm section of lumbar spinal cord of guinea pigs was irradiated with fractionated doses of 4.5 Gy gamma rays given as 9 fractions per week. Guinea pigs were primed with 9 x 4.5 Gy in 7 days which is 60% of the ED[sub 50] for a continuous course of treatment. After 28 or 40 weeks, animal were retreated with 6-14 fractions of 4.5 Gy. Animals were observed for 2 years following the priming dose and both the incidence and latency of myelopathy recorded. Young adult guinea pigs (8 wk old) showed both a decreased radiation tolerance and latency compared to old individuals (40 wk old). At 28 or 40 wk after 9 x 4.5 Gy, only about 8% of the initial injury was remembered in young adult guinea pigs. The amount of residual injury was dependent on the initial damage as a proportion of the tolerance dose. The spinal cord shows a greater capacity for long-term recovery than generally appreciated and re-treatment doses clinically prescribed may be lower than necessary. 8 refs., 3 figs., 2 tabs.},
doi = {10.1016/0360-3016(93)90282-Z},
journal = {International Journal of Radiation Oncology, Biology and Physics; (United States)},
issn = {0360-3016},
number = ,
volume = 26:4,
place = {United States},
year = {1993},
month = {7}
}