Late effects of radiation on the lumbar spinal cord of guinea pigs: Re-treatment tolerance
- Univ. of Texas M.D. Anderson Cancer Center, Houston, TX (United States)
- Univ. of California, Los Angeles, CA (United States)
Using a guinea pig model of lumbar myelopathy, various factors affecting the tolerance of spinal cord to irradiation were assessed: (a) extent of initial injury; (b) time interval between priming and test doses; and (c) animal age at the time of initial radiation treatment. A 3 cm section of lumbar spinal cord of guinea pigs was irradiated with fractionated doses of 4.5 Gy gamma rays given as 9 fractions per week. Guinea pigs were primed with 9 x 4.5 Gy in 7 days which is 60% of the ED[sub 50] for a continuous course of treatment. After 28 or 40 weeks, animal were retreated with 6-14 fractions of 4.5 Gy. Animals were observed for 2 years following the priming dose and both the incidence and latency of myelopathy recorded. Young adult guinea pigs (8 wk old) showed both a decreased radiation tolerance and latency compared to old individuals (40 wk old). At 28 or 40 wk after 9 x 4.5 Gy, only about 8% of the initial injury was remembered in young adult guinea pigs. The amount of residual injury was dependent on the initial damage as a proportion of the tolerance dose. The spinal cord shows a greater capacity for long-term recovery than generally appreciated and re-treatment doses clinically prescribed may be lower than necessary. 8 refs., 3 figs., 2 tabs.
- OSTI ID:
- 6694866
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics; (United States), Vol. 26:4; ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
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RADIOTHERAPY
SIDE EFFECTS
SPINAL CORD
RADIATION INJURIES
FRACTIONATED IRRADIATION
BIOLOGICAL EFFECTS
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CENTRAL NERVOUS SYSTEM
INJURIES
IRRADIATION
MEDICINE
NERVOUS SYSTEM
NUCLEAR MEDICINE
RADIATION EFFECTS
RADIOLOGY
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560152* - Radiation Effects on Animals- Animals