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Title: Clinical comparison of cardiac blood pool visualization with technetium-99m red blood cells labeled in vivo and with technetium-99m human serum albumin

Abstract

Technetium-99m red blood cells (Tc-RBC) labeled by an in vivo technique were compared with two preparations of Tc-99m human serum albumin (HSA) for cardiac blood-pool imaging. Relative distribution of the tracers was analyzed on end-diastolic frames of gated blood-pool studies and on whole-body (head to mid-thigh) anterior pinhole images. The Tc-RBC demonstrated greater relative percentage localization in the cardiac blood pool, higher target-to-background ratios in the left ventricle, and less liver concentration. For cardiac blood-pool imaging, Tc-RBC labeled by the in vivo approach appears to be superior to the two Tc-HSA preparations studied.

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
Univ. of Michigan Medical Center, Ann Arbor, MI
OSTI Identifier:
6688352
Resource Type:
Journal Article
Journal Name:
J. Nucl. Med.; (United States)
Additional Journal Information:
Journal Volume: 19:7
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ALBUMINS; RADIOPHARMACEUTICALS; BLOOD CIRCULATION; MEASURING METHODS; ERYTHROCYTES; LABELLING; HEART; SCINTISCANNING; BIOLOGICAL LOCALIZATION; COMPARATIVE EVALUATIONS; TECHNETIUM 99; BLOOD SERUM; IN VIVO; ISOMERIC NUCLEI; LABELLED COMPOUNDS; PATIENTS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CARDIOVASCULAR SYSTEM; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DRUGS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING; RADIOISOTOPES; TECHNETIUM ISOTOPES; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Thrall, J H, Freitas, J E, Swanson, D, Rogers, W L, Clare, J M, Brown, M L, and Pitt, B. Clinical comparison of cardiac blood pool visualization with technetium-99m red blood cells labeled in vivo and with technetium-99m human serum albumin. United States: N. p., 1978. Web.
Thrall, J H, Freitas, J E, Swanson, D, Rogers, W L, Clare, J M, Brown, M L, & Pitt, B. Clinical comparison of cardiac blood pool visualization with technetium-99m red blood cells labeled in vivo and with technetium-99m human serum albumin. United States.
Thrall, J H, Freitas, J E, Swanson, D, Rogers, W L, Clare, J M, Brown, M L, and Pitt, B. 1978. "Clinical comparison of cardiac blood pool visualization with technetium-99m red blood cells labeled in vivo and with technetium-99m human serum albumin". United States.
@article{osti_6688352,
title = {Clinical comparison of cardiac blood pool visualization with technetium-99m red blood cells labeled in vivo and with technetium-99m human serum albumin},
author = {Thrall, J H and Freitas, J E and Swanson, D and Rogers, W L and Clare, J M and Brown, M L and Pitt, B},
abstractNote = {Technetium-99m red blood cells (Tc-RBC) labeled by an in vivo technique were compared with two preparations of Tc-99m human serum albumin (HSA) for cardiac blood-pool imaging. Relative distribution of the tracers was analyzed on end-diastolic frames of gated blood-pool studies and on whole-body (head to mid-thigh) anterior pinhole images. The Tc-RBC demonstrated greater relative percentage localization in the cardiac blood pool, higher target-to-background ratios in the left ventricle, and less liver concentration. For cardiac blood-pool imaging, Tc-RBC labeled by the in vivo approach appears to be superior to the two Tc-HSA preparations studied.},
doi = {},
url = {https://www.osti.gov/biblio/6688352}, journal = {J. Nucl. Med.; (United States)},
number = ,
volume = 19:7,
place = {United States},
year = {Sat Jul 01 00:00:00 EDT 1978},
month = {Sat Jul 01 00:00:00 EDT 1978}
}