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Title: Increased urinary beta 2-microglobulin in cadmium exposure: dose-effect relationship and biological significance of beta 2-microglobulin

Abstract

A study on the general population from both cadmium-polluted and control areas and on cadmium alloy workers indicates that beta 2-MG in urine is very closely correlated with aging, but it indicates an association with cadmium exposure. However, the age factor is stronger than cadmium exposure in both polluted and control areas among persons without clinical proteinuria. On the other hand, cadmium exposure is most likely correlated with beta 2-MG even in nonpolluted areas. Beta 2-MG in serum indicated a very close correlation with cadmium in blood among cadmium alloy workers. This may suggest that an increase of beta 2-MG in both blood and urine in an early stage of cadmium exposure is caused by the increased level of beta 2-MG in blood.

Authors:
; ; ;
Publication Date:
Research Org.:
Univ. of Occupational and Environmental Health, Kitakyushu, Japan
OSTI Identifier:
6671537
Alternate Identifier(s):
OSTI ID: 6671537
Resource Type:
Journal Article
Journal Name:
Environ. Health Perspect.; (United States)
Additional Journal Information:
Journal Volume: 28
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BLOOD SERUM; COMPARATIVE EVALUATIONS; CADMIUM; ENVIRONMENTAL EXPOSURE PATHWAY; HEALTH HAZARDS; GLOBULINS; QUANTITY RATIO; AGE DEPENDENCE; URINE; DOSE-RESPONSE RELATIONSHIPS; HUMAN POPULATIONS; PERSONNEL; UROGENITAL SYSTEM DISEASES; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY FLUIDS; DISEASES; ELEMENTS; HAZARDS; MATERIALS; METALS; ORGANIC COMPOUNDS; POPULATIONS; PROTEINS; WASTES 560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)

Citation Formats

Tsuchiya, K., Iwao, S., Sugita, M., and Sakurai, H. Increased urinary beta 2-microglobulin in cadmium exposure: dose-effect relationship and biological significance of beta 2-microglobulin. United States: N. p., 1979. Web. doi:10.2307/3428917.
Tsuchiya, K., Iwao, S., Sugita, M., & Sakurai, H. Increased urinary beta 2-microglobulin in cadmium exposure: dose-effect relationship and biological significance of beta 2-microglobulin. United States. doi:10.2307/3428917.
Tsuchiya, K., Iwao, S., Sugita, M., and Sakurai, H. Thu . "Increased urinary beta 2-microglobulin in cadmium exposure: dose-effect relationship and biological significance of beta 2-microglobulin". United States. doi:10.2307/3428917.
@article{osti_6671537,
title = {Increased urinary beta 2-microglobulin in cadmium exposure: dose-effect relationship and biological significance of beta 2-microglobulin},
author = {Tsuchiya, K. and Iwao, S. and Sugita, M. and Sakurai, H.},
abstractNote = {A study on the general population from both cadmium-polluted and control areas and on cadmium alloy workers indicates that beta 2-MG in urine is very closely correlated with aging, but it indicates an association with cadmium exposure. However, the age factor is stronger than cadmium exposure in both polluted and control areas among persons without clinical proteinuria. On the other hand, cadmium exposure is most likely correlated with beta 2-MG even in nonpolluted areas. Beta 2-MG in serum indicated a very close correlation with cadmium in blood among cadmium alloy workers. This may suggest that an increase of beta 2-MG in both blood and urine in an early stage of cadmium exposure is caused by the increased level of beta 2-MG in blood.},
doi = {10.2307/3428917},
journal = {Environ. Health Perspect.; (United States)},
number = ,
volume = 28,
place = {United States},
year = {1979},
month = {2}
}