New osmium-191. -->. iridium-191m generator
A new osmium-191..-->..iridium-191m generator suitable for first-pass radionuclide angiocardiography has been developed. This generator system allows repeated elutions of 4.96-sec iridium-191m from its 15.4-day Os-191 parent. The Os-191 is loaded on an anion-exchange column (AGMP-1) and Ir-191m eluted with 0.9% NaCl at pH 1. Each elution (0.6 to 1 ml) of the generator yields about 7 to 10% Ir-191m and gives 0.003 to 0.008% of Os-191 breakthrough. Toxicity studies of the generator eluate carried out in animals support the safety of using iridium-191m in humans. The long shelf-life of the generator (approx. = 2 wk) will allow medical centers to use Ir-191m for routine clinical diagnosis. Iridium-191m obtained by this method should find additional useful applications in nuclear medicine.
- Research Organization:
- Harvard Medical School, Boston, MA
- DOE Contract Number:
- EY-76-S-4155
- OSTI ID:
- 6667523
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 21:12
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
IRIDIUM 191
DIAGNOSTIC USES
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
BIOLOGICAL HALF-LIFE
COMPARATIVE EVALUATIONS
DYNAMIC FUNCTION STUDIES
ISOMERIC NUCLEI
OSMIUM 191
PATIENTS
RADIATION DOSES
RADIOISOTOPE GENERATORS
RADIONUCLIDE KINETICS
SCINTISCANNING
TOXICITY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DOSES
DRUGS
EVEN-ODD NUCLEI
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IRIDIUM ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
OSMIUM ISOTOPES
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
STABLE ISOTOPES
SYNTHESIS
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques
400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials