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Title: Thermal and molecular investigation of laser tissue welding

Abstract

Despite the growing number of successful animal and human trials, the exact mechanisms of laser tissue welding remain unknown. Furthermore, the effects of laser heating on tissue on the molecular scale are not fully understood. To address these issues, a multi-front attack oil both extrinsic (solder/patch mediated) and intrinsic (laser only) tissue welding was launched using two-color infrared thermometry, computer modeling, weld strength assessment, biochemical assays, and vibrational spectroscopy. The coupling of experimentally measured surface temperatures with the predictive numerical simulations provided insight into the sub-surface dynamics of the laser tissue welding process. Quantification of the acute strength of the welds following the welding procedure enabled comparison among trials during an experiment, with previous experiments, and with other studies in the literature. The acute weld integrity also provided an indication of tile probability of long-term success. Molecular effects induced In the tissue by laser irradiation were investigated by measuring tile concentrations of specific collagen covalent crosslinks and characterizing the Fourier-Transform infrared (FTIR) spectra before and after the laser exposure.

Authors:
Publication Date:
Research Org.:
Lawrence Livermore National Lab., CA (United States)
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
665645
Report Number(s):
UCRL-LR-130533
ON: DE98057748; BR: YN0100000; CNN: W-7405-Eng-48
DOE Contract Number:
W-7405-ENG-48
Resource Type:
Technical Report
Resource Relation:
Other Information: PBD: 1 Jun 1998
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; LASERS; WELDING; ANIMAL TISSUES; MATHEMATICAL MODELS; SPECTROSCOPY; IRRADIATION; MOLECULAR STRUCTURE

Citation Formats

Small, W., IV. Thermal and molecular investigation of laser tissue welding. United States: N. p., 1998. Web. doi:10.2172/665645.
Small, W., IV. Thermal and molecular investigation of laser tissue welding. United States. doi:10.2172/665645.
Small, W., IV. Mon . "Thermal and molecular investigation of laser tissue welding". United States. doi:10.2172/665645. https://www.osti.gov/servlets/purl/665645.
@article{osti_665645,
title = {Thermal and molecular investigation of laser tissue welding},
author = {Small, W., IV},
abstractNote = {Despite the growing number of successful animal and human trials, the exact mechanisms of laser tissue welding remain unknown. Furthermore, the effects of laser heating on tissue on the molecular scale are not fully understood. To address these issues, a multi-front attack oil both extrinsic (solder/patch mediated) and intrinsic (laser only) tissue welding was launched using two-color infrared thermometry, computer modeling, weld strength assessment, biochemical assays, and vibrational spectroscopy. The coupling of experimentally measured surface temperatures with the predictive numerical simulations provided insight into the sub-surface dynamics of the laser tissue welding process. Quantification of the acute strength of the welds following the welding procedure enabled comparison among trials during an experiment, with previous experiments, and with other studies in the literature. The acute weld integrity also provided an indication of tile probability of long-term success. Molecular effects induced In the tissue by laser irradiation were investigated by measuring tile concentrations of specific collagen covalent crosslinks and characterizing the Fourier-Transform infrared (FTIR) spectra before and after the laser exposure.},
doi = {10.2172/665645},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Jun 01 00:00:00 EDT 1998},
month = {Mon Jun 01 00:00:00 EDT 1998}
}

Technical Report:

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