Brain acetylcholinesterase activity recovery following acute methyl parathion intoxication in two feral rodent species: comparison to laboratory rodents
Widespread use of organophosphorus insecticides (OPs) has produced both acute and chronic intoxication among nontarget organisms. Most such studies have included fish and birds as opposed to mammals. However, numerous OP toxicity studies have been conducted on laboratory rodents creating a temptation to apply this data to feral rodents. Chronic OP exposure has been reported to produce cholinergic adaptation which in turn lowers mortality rates following a subsequent acute anticholinesterase exposure. The relevance that these laboratory rodent studies have on feral rodents is subject to debate. Field studies involving OP exposure among nontarget feral mammals have produced contradictory results. Increased mortality as a result of repeated OP application has been reported. This observation may be of considerable importance to nontarget feral rodent populations due to the repetitive nature of OP application protocols. The ability of feral rodents to recover brain AChE activity (BAA) between OP application intervals undoubtedly promotes their survival. This study investigated and compared BAA recovery following acute oral methyl parathion intoxication among 2 feral rodent species and among 2 common laboratory rodent species.
- Research Organization:
- Texas A and M Univ., College Station (USA)
- OSTI ID:
- 6647868
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Vol. 41:1
- Country of Publication:
- United States
- Language:
- English
Similar Records
Spatiotemporal pattern of neuronal injury induced by DFP in rats: A model for delayed neuronal cell death following acute OP intoxication
Comparative effects of parathion and chlorpyrifos on extracellular endocannabinoid levels in rat hippocampus: Influence on cholinergic toxicity
Related Subjects
BRAIN
ENZYME ACTIVITY
CHOLINESTERASE
BIOCHEMISTRY
PARATHION
CHRONIC EXPOSURE
ACETYLCHOLINE
LABORATORY ANIMALS
MORTALITY
RODENTS
THIOPHOSPHORIC ACID ESTERS
TOXICITY
AMINES
AMMONIUM COMPOUNDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
CARBOXYLESTERASES
CENTRAL NERVOUS SYSTEM
CHEMISTRY
DRUGS
ENZYMES
ESTERASES
ESTERS
HYDROLASES
INSECTICIDES
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PARASYMPATHOMIMETICS
PESTICIDES
QUATERNARY COMPOUNDS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology