Radioimmunoassay for thyroid-stimulating hormone (TSH)
Patent
·
OSTI ID:6631417
This invention provides a method for the radioimmunoassay of thyroid-stimulating hormone which utilizes a rapid and convenient version of a double antibody procedure. Highly purified second antibody is bound, by means of covalent bonds, to hydrolyzed polyacrylamide particles to produce a two-phase system. The solid phase comprises immobilized second antibody bound to the reaction product of labeled and unlabeled thyroid-stimulating hormone with the first antibody (first antibody-antigen complex) and the liquid phase comprises free (unbound) labeled and unlabeled thyroid-stimulating hormone. The two phases are separated and the radioactivity of either phase is measured.
- Assignee:
- Bio-Rad Laboratories, Inc.
- Patent Number(s):
- US 4088746
- Application Number:
- TRN: 79-001373
- OSTI ID:
- 6631417
- Resource Relation:
- Patent File Date: Filed date 11 Nov 1976
- Country of Publication:
- United States
- Language:
- English
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+1 more
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
TSH
RADIOIMMUNOASSAY
ANTIBODIES
ANTIGEN-ANTIBODY REACTIONS
BLOOD SERUM
IMMUNE SERUMS
IODINE 125
LABELLED COMPOUNDS
MAN
ANIMALS
BETA DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
HORMONES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
PEPTIDE HORMONES
PITUITARY HORMONES
PRIMATES
RADIOASSAY
RADIOISOTOPES
TRACER TECHNIQUES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
TSH
RADIOIMMUNOASSAY
ANTIBODIES
ANTIGEN-ANTIBODY REACTIONS
BLOOD SERUM
IMMUNE SERUMS
IODINE 125
LABELLED COMPOUNDS
MAN
ANIMALS
BETA DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
HORMONES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
PEPTIDE HORMONES
PITUITARY HORMONES
PRIMATES
RADIOASSAY
RADIOISOTOPES
TRACER TECHNIQUES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics