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Title: Profound radiosensitivity in leukemic T-cell lines and T-cell-type acute lymphoblastic leukemia demonstrated by sodium (51Cr)chromate labeling

Abstract

Radiation sensitivity was determined by measuring spontaneous release from /sup 51/Cr-labeled cells in various lymphoid cell populations. Among six leukemia T-cell lines originating from acute lymphoblastic leukemia, four such lines were found to be highly radiosensitive. In contrast, two of the leukemic T-cell lines and four normal control B-cell lines were not radiosensitive. Thymocytes from six patients and leukemia T-cell blasts from three patients with T-cell leukemia were likewise found to be highly radiosensitive, whereas leukemic blasts from six patients with null-cell (non-T, non-B-cell) acute lymphoblastic leukemia were not radiosensitive. Normal peripheral blood lymphocytes and mitogen-induced normal lymphoblasts were found not to be radiosensitive. The results indicate that measurement of the radiation sensitivity of acute leukemic blasts may have a therapeutic significance in coping with the heterogeneous nature of individual leukemia cases.

Authors:
; ; ;
Publication Date:
Research Org.:
New York State Dept. of Health, Buffalo
OSTI Identifier:
6623258
Resource Type:
Journal Article
Journal Name:
Cancer Res.; (United States)
Additional Journal Information:
Journal Volume: 38:6
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ANIMAL CELLS; RADIOSENSITIVITY; CHROMIUM 51; DIAGNOSTIC USES; LEUKEMIA; THERAPY; BIOLOGICAL RADIATION EFFECTS; IN VITRO; LABELLED COMPOUNDS; SODIUM COMPOUNDS; THYMOCYTES; ALKALI METAL COMPOUNDS; BETA DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; CHROMIUM ISOTOPES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; HEMIC DISEASES; INTERMEDIATE MASS NUCLEI; ISOTOPES; NEOPLASMS; NUCLEI; RADIATION EFFECTS; RADIOISOTOPES; SOMATIC CELLS; USES; 560122* - Radiation Effects on Cells- Internal Source- (-1987)

Citation Formats

Nakazawa, S, Minowada, J, Tsubota, T, and Sinks, L F. Profound radiosensitivity in leukemic T-cell lines and T-cell-type acute lymphoblastic leukemia demonstrated by sodium (51Cr)chromate labeling. United States: N. p., 1978. Web.
Nakazawa, S, Minowada, J, Tsubota, T, & Sinks, L F. Profound radiosensitivity in leukemic T-cell lines and T-cell-type acute lymphoblastic leukemia demonstrated by sodium (51Cr)chromate labeling. United States.
Nakazawa, S, Minowada, J, Tsubota, T, and Sinks, L F. 1978. "Profound radiosensitivity in leukemic T-cell lines and T-cell-type acute lymphoblastic leukemia demonstrated by sodium (51Cr)chromate labeling". United States.
@article{osti_6623258,
title = {Profound radiosensitivity in leukemic T-cell lines and T-cell-type acute lymphoblastic leukemia demonstrated by sodium (51Cr)chromate labeling},
author = {Nakazawa, S and Minowada, J and Tsubota, T and Sinks, L F},
abstractNote = {Radiation sensitivity was determined by measuring spontaneous release from /sup 51/Cr-labeled cells in various lymphoid cell populations. Among six leukemia T-cell lines originating from acute lymphoblastic leukemia, four such lines were found to be highly radiosensitive. In contrast, two of the leukemic T-cell lines and four normal control B-cell lines were not radiosensitive. Thymocytes from six patients and leukemia T-cell blasts from three patients with T-cell leukemia were likewise found to be highly radiosensitive, whereas leukemic blasts from six patients with null-cell (non-T, non-B-cell) acute lymphoblastic leukemia were not radiosensitive. Normal peripheral blood lymphocytes and mitogen-induced normal lymphoblasts were found not to be radiosensitive. The results indicate that measurement of the radiation sensitivity of acute leukemic blasts may have a therapeutic significance in coping with the heterogeneous nature of individual leukemia cases.},
doi = {},
url = {https://www.osti.gov/biblio/6623258}, journal = {Cancer Res.; (United States)},
number = ,
volume = 38:6,
place = {United States},
year = {Thu Jun 01 00:00:00 EDT 1978},
month = {Thu Jun 01 00:00:00 EDT 1978}
}