Quantitative in vivo measurements of tumor perfusion using rubidium-81 and positron emission tomography
- Royal Marsden Hospital, Sutton (England)
Rubidium-81 (t1/2 = 4.58 hr) was investigated as a tumor perfusion tracer in the VX2 carcinoma implanted into rabbit thigh muscle using a large-area, multiwire proportional chamber positron emission tomography (PET) system. Perfusion was determined using the arterial reference sample method, and the results from PET imaging were compared with postmortem tissue sampling. Absolute quantitation of tumor perfusion was achieved using external probes to estimate local extraction fraction. Redistribution of rubidium-81 (81Rb) was investigated using a dual-tracer technique. Average perfusion was found to be 13.5 and 3.7 ml/min/100 g in tumor and normal muscle, respectively. The extraction fraction as estimated from a two-compartment model ranged from 0.94 to 1.00. No significant redistribution of 81Rb was observed in these tissues. Nine patients with malignancies were studied using 81Rb and PET. Tumor perfusion in four patients with carcinoma of the breast was elevated by a factor of 1.8 (range 1.2-2.3) compared to contralateral normal breast.
- OSTI ID:
- 6620005
- Journal Information:
- Journal of Nuclear Medicine; (USA), Vol. 31:8; ISSN 0161-5505
- Country of Publication:
- United States
- Language:
- English
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CARCINOMAS
DIAGNOSIS
MAMMARY GLANDS
EXPERIMENTAL NEOPLASMS
MAN
MUSCLES
PERFUSED TISSUES
POSITRON COMPUTED TOMOGRAPHY
RABBITS
RUBIDIUM 81
TUMOR CELLS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
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DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PRIMATES
RADIOISOTOPES
RUBIDIUM ISOTO
TISSUES
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550601* - Medicine- Unsealed Radionuclides in Diagnostics