Body fluid volumes in rats with mestranol-induced hypertension
Because estrogens have been reported to produce sodium retention, this study investigated the possibility that hypertension in rats resulting from the ingestion of an estrogen used as an oral contraceptive could be due to increases in body fluid volumes. Female rats were given feed containing mestranol for 1, 3, and 6 mo; control rats were given the feed without mestranol. The mestranol-treated rats had higher arterial pressures than the controls only after 6 mo of treatment. Plasma volume, extracellular fluid volume, and total body water were measured in each rat by the distribution volumes of radioiodinated serum albumin, /sup 32/SO/sub 4/, and tritiated water, respectively. The body fluid volumes, expressed per 100 g of body weight, were not different between the mestranol-treated rats and their controls at any of the three treatment times. Due to differences in body weight and lean body mass between the mestranol-treated and the control rats, these volumes also were expressed per 100 g of lean body mass. Again, no differences were observed between the mestranol-treated rats and the control rats for any of these body fluid compartments at any of the treatment times. These studies, therefore, were unable to provide evidence that increases in body fluid volumes contributed to the elevated arterial pressure in this rat model of oral contraceptive hypertension.
- Research Organization:
- Univ. of Missouri School of Medicine, Columbia
- OSTI ID:
- 6613928
- Journal Information:
- Am. J. Physiol.; (United States), Vol. 251:1
- Country of Publication:
- United States
- Language:
- English
Similar Records
Age-related changes in body fluid volumes in young spontaneously hypertensive rats
Effects of altered platelet number on pulmonary hypertension and platelet sequestration in monocrotaline pyrrole-treated rats
Related Subjects
BODY FLUIDS
VOLUME
ESTROGENS
BIOLOGICAL EFFECTS
LABELLED COMPOUNDS
TISSUE DISTRIBUTION
ALBUMINS
FEMALES
HYPERTENSION
IODINE 125
RATS
SULFATES
SULFUR 35
TRITIUM COMPOUNDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
CARDIOVASCULAR DISEASES
DAYS LIVING RADIOISOTOPES
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HORMONES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
LIGHT NUCLEI
MAMMALS
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
PROTEINS
RADIOISOTOPES
RODENTS
STEROID HORMONES
SULFUR COMPOUNDS
SULFUR ISOTOPES
SYMPTOMS
VASCULAR DISEASES
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques