Determination of lead in paired samples of human blood and synovial fluid

Journal Article · Tue Sep 01 00:00:00 EDT 1992 · Bulletin of Environmental Contamination and Toxicology; (United States)

DOI:https://doi.org/10.1007/BF01239642· OSTI ID:6613482

Villegas-Navarro, A; Rosales, D; Bustos, E; Reyes, R; Reyes, J L; Dieck, T A; Heredia, A ^[1]

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1. Unidad de Investigacion Biomedica del Noreste del I.M.S.S., Monterrey (Mexico)

In spite of the numerous papers published on the toxicity of lead in mammals, little is known about its effects in synovial fluid and bone joints. Our literature search showed a lack of quantitative studies regarding the concentration of lead in human synovial fluid; in addition, normal values regarding the threshold for poisoning by lead in that fluid are unknown. The available literature published corresponds to samples of human wounds by lead bullets localized close to or in a joint. Some of those papers dealing with lead-induced arthritis include symptoms of plumbism. They clearly demonstrate the ability of synovial fluid to dissolve lead and thereby make it available for systemic absorption. The molecular mechanism whereby this process is performed is still unknown, although it would be of interest because of its possible relationship with joint pain, a common problem in patients with lead poisoning that so far has not been fully explained. In a series of experiments with cattle, we found an average ratio of lead between synovial fluid and blood for paired observations of 4.2, although we have not found similar reports, and there is not sufficient information to make a total interpretation of these data. The purpose of this study was to determine the concentration of lead in synovial fluid and blood of corpses and to establish a possible numerical relationship between those two variables. 19 refs., 1 fig., 1 tab.

• OSTI ID: 6613482
• Journal Information: Bulletin of Environmental Contamination and Toxicology; (United States), Vol. 49:3; ISSN 0007-4861
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BODY FLUIDS
CONTAMINATION
LEAD
BIOLOGICAL ACCUMULATION
ECOLOGICAL CONCENTRATION
BLOOD
BONE JOINTS
MAN
ANIMALS
BIOLOGICAL MATERIALS
BODY
ELEMENTS
MAMMALS
MATERIALS
METALS
ORGANS
PRIMATES
SKELETON
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology