Development of relative potency estimates for PAHs and hydrocarbon combustion product fractions compared to benzo(a)pyrene and their use in carcinogenic risk assessments
As an extension of the work started in a previous contract (EPA 68-02-4403, April 1988), various approaches for estimating the carcinogenic potency of polycyclic aromatic hydrocarbons (PAH) mixtures were investigated. The approach uses the two-stage model described in the previous contract work to convert the tumor incidence data in a variety of bioassays to a low-dose linear slope of the dose-response curve. The potency of mixtures and components of mixtures is expressed as a fraction of the potency of benzo(a)pyrene (B(a)P), which is treated as a reference standard. The basic assumption of the method is that the relative potency of the mixture is the weighted average of the relative potency of the components. The method is applied to data generated by a single group of investigators on lung cancer in female Osborne-Mendel rats induced by implantation of test material in the lung. Diesel engine exhaust, gasoline engine exhaust, flue gas condensate from coal-fired furnances and sidestream cigarette smoke were tested, along with their identified chemical components and solvent-extracted components. Of nine different procedures for evaluating the relative potency of combustion product mixtures from their components, the most accurate one assumes that the relative potency of the solvent-extracted fraction containing greater than three rings is equal to B(a)P.
- Research Organization:
- Clement International Corp., Fairfax, VA (United States)
- OSTI ID:
- 6611996
- Report Number(s):
- PB-93-161008/XAB; CNN: EPA-68-02-4601
- Resource Relation:
- Other Information: See also PB--84-182377
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
DIAGNOSTIC TECHNIQUES
COMPARATIVE EVALUATIONS
POLYCYCLIC AROMATIC HYDROCARBONS
CARCINOGEN SCREENING
AIR POLLUTION
BENZOPYRENE
CHEMICAL ANALYSIS
COAL
COMBUSTION PRODUCTS
DIESEL ENGINES
DOSE-RESPONSE RELATIONSHIPS
EXHAUST SYSTEMS
FLUE GAS
GASOLINE
LABORATORY ANIMALS
LUNGS
NEOPLASMS
PUBLIC HEALTH
RATS
RESEARCH PROGRAMS
RISK ASSESSMENT
STATISTICAL DATA
TOBACCO PRODUCTS
ANIMALS
AROMATICS
BODY
CARBONACEOUS MATERIALS
CONDENSED AROMATICS
DATA
DISEASES
ENERGY SOURCES
ENGINES
EVALUATION
FOSSIL FUELS
FUELS
GASEOUS WASTES
HEAT ENGINES
HYDROCARBONS
INFORMATION
INTERNAL COMBUSTION ENGINES
LIQUID FUELS
MAMMALS
MATERIALS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
PETROLEUM PRODUCTS
POLLUTION
RESPIRATORY SYSTEM
RODENTS
SCREENING
VERTEBRATES
WASTES
560300* - Chemicals Metabolism & Toxicology
550900 - Pathology