Coal: response of cultured mammalian cells corresponds to the prevalence of coal workers pneumoconiosis
The growth of mammalian cells is inhibited when leachates of coal are incorporated into the growth medium. Coal samples in these experiments are exposed to water, calf serum, or tissue culture medium under physiological conditions of temperature and pH. The coal sample from a mine whose miners had a very high incidence of coal workers pneumoconiosis. ''Black Lung Disease,'' inhibited the growth of cells much more than coal from another mine whose miners showed a much lower prevalence of the disease. The cellular growth inhibition was related linearly to the logarithm of the concentration of the coal leachates. Several metals in the leachate were determined in an attempt to determine the toxic substances leached from the coal.
- Research Organization:
- Univ. of Cincinnati
- OSTI ID:
- 6605460
- Journal Information:
- Environ. Res.; (United States), Vol. 15:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
01 COAL, LIGNITE, AND PEAT
CELL CULTURES
INHIBITION
COAL
BIOLOGICAL EFFECTS
BIOASSAY
CULTURE MEDIA
DOSE-RESPONSE RELATIONSHIPS
GROWTH
IN VITRO
MAMMALS
METALS
NICKEL
NICKEL CHLORIDES
OCCUPATIONAL DISEASES
PNEUMOCONIOSES
TOXICITY
ANIMALS
CARBONACEOUS MATERIALS
CHLORIDES
CHLORINE COMPOUNDS
DISEASES
ELEMENTS
ENERGY SOURCES
FOSSIL FUELS
FUELS
HALIDES
HALOGEN COMPOUNDS
NICKEL COMPOUNDS
RESPIRATORY SYSTEM DISEASES
TRANSITION ELEMENT COMPOUNDS
TRANSITION ELEMENTS
VERTEBRATES
560301* - Chemicals Metabolism & Toxicology- Cells- (-1987)
016000 - Coal
Lignite
& Peat- Health & Safety