Response to. gamma. radiation of mice with spontaneous chromosome instability (NZB mice). [/sup 60/Co]

Journal Article · Thu Jan 01 00:00:00 EST 1981 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575449· OSTI ID:6598342

Emerit, I ^[1]; Riklis, E; Bernard, C; Feingold, J

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1. Universite Pierre et Marie Curie, Paris, France

In New Zealand Black (NZB) mice, chromosomal instability is associated with a high risk of lymphoreticular neoplasia. Since this association is related in ataxia telangiectasia to a particular sensitivity to ionizing radiation, the radiosensitivity of NZB mice was studied. The results are not in favor of an abnormal radiosensitivity as judged by the incidence of chromosome damage and postirradiation lethality. The increase in chromosome breaks and rearrangements is due to an excess in aberration production rather than to a defective repair of DNA.

• OSTI ID: 6598342
• Journal Information: Radiat. Res.; (United States), Vol. 85:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL REPAIR
BIOLOGICAL RADIATION EFFECTS
CHROMOSOMAL ABERRATIONS
CORRELATIONS
RADIOINDUCTION
CHROMOSOMES
NEOPLASMS
COBALT 60
GAMMA RADIATION
MICE
TELANGIECTASIS
WHOLE-BODY IRRADIATION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
COBALT ISOTOPES
DISEASES
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
MUTATIONS
NUCLEI
ODD-ODD NUCLEI
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RECOVERY
REPAIR
RODENTS
SKIN DISEASES
VASCULAR DISEASES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals