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Title: Comparative mutagenesis. Progress report, January 1, 1977-December 31, 1977 (extended from January 1, 1978-December 31,1978

Abstract

Our major research efforts have been on the mutagenicity of certain ICR-compounds and on studies in environmental mutagenesis. From a comparison of the mutagenicity of 16 ICR-compounds, we concluded that Neurospora crassa is a better predictor than Salmonella typhimurium of antitumor and carcinogenic potencies in mice. Streptonigrin induced a high frequency (25%) of multilocus deletions at the ad-3 region of N. crassa. Most of the water concentrates prepared from Lake Bloomington, IL were weakly mutagenic in the Salmonella/microsome test; one concentrate was highly mutagenic in strain TA100. Chemical analysis of the highly mutagenic concentrate revealed the presence of a number of organic compounds that were absent or very low in the weakly mutagenic concentrates. Cigarette smoke condensate and certain factions of the condensate were mutagenic in N. crassa, Saccharomyces cerevisiae, and Drosophila melanogaster. In D. melanogaster, cigarette smoke also was mutagenic. In N. crassa, cigarette smoke condensate appeared to be direct acting. Sodium azide was not mutagenic in N. crassa at pH values of 3 to 8, and there were no significant differences in the induced reversion frequencies over this pH range in S. typhimurium.

Authors:
Publication Date:
Research Org.:
Illinois State Univ., Normal (USA)
Sponsoring Org.:
USDOE
OSTI Identifier:
6594384
Alternate Identifier(s):
OSTI ID: 6594384
Report Number(s):
COO--1314-37
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; MUTAGEN SCREENING; RESEARCH PROGRAMS; AZIDES; DRINKING WATER; DROSOPHILA; DRUGS; NEUROSPORA; ORGANIC COMPOUNDS; SACCHAROMYCES CEREVISIAE; SALMONELLA TYPHIMURIUM; TOBACCO SMOKES; AEROSOLS; ANIMALS; ARTHROPODS; BACTERIA; COLLOIDS; DISPERSIONS; FLIES; FRUIT FLIES; FUNGI; HYDROGEN COMPOUNDS; INSECTS; INVERTEBRATES; MICROORGANISMS; NITROGEN COMPOUNDS; OXYGEN COMPOUNDS; PLANTS; RESIDUES; SACCHAROMYCES; SALMONELLA; SCREENING; SMOKES; SOLS; WATER; YEASTS 560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987); 560304 -- Chemicals Metabolism & Toxicology-- Invertebrates-- (-1987)

Citation Formats

Brockman, H.E. Comparative mutagenesis. Progress report, January 1, 1977-December 31, 1977 (extended from January 1, 1978-December 31,1978. United States: N. p., 1978. Web. doi:10.2172/6594384.
Brockman, H.E. Comparative mutagenesis. Progress report, January 1, 1977-December 31, 1977 (extended from January 1, 1978-December 31,1978. United States. doi:10.2172/6594384.
Brockman, H.E. Fri . "Comparative mutagenesis. Progress report, January 1, 1977-December 31, 1977 (extended from January 1, 1978-December 31,1978". United States. doi:10.2172/6594384. https://www.osti.gov/servlets/purl/6594384.
@article{osti_6594384,
title = {Comparative mutagenesis. Progress report, January 1, 1977-December 31, 1977 (extended from January 1, 1978-December 31,1978},
author = {Brockman, H.E.},
abstractNote = {Our major research efforts have been on the mutagenicity of certain ICR-compounds and on studies in environmental mutagenesis. From a comparison of the mutagenicity of 16 ICR-compounds, we concluded that Neurospora crassa is a better predictor than Salmonella typhimurium of antitumor and carcinogenic potencies in mice. Streptonigrin induced a high frequency (25%) of multilocus deletions at the ad-3 region of N. crassa. Most of the water concentrates prepared from Lake Bloomington, IL were weakly mutagenic in the Salmonella/microsome test; one concentrate was highly mutagenic in strain TA100. Chemical analysis of the highly mutagenic concentrate revealed the presence of a number of organic compounds that were absent or very low in the weakly mutagenic concentrates. Cigarette smoke condensate and certain factions of the condensate were mutagenic in N. crassa, Saccharomyces cerevisiae, and Drosophila melanogaster. In D. melanogaster, cigarette smoke also was mutagenic. In N. crassa, cigarette smoke condensate appeared to be direct acting. Sodium azide was not mutagenic in N. crassa at pH values of 3 to 8, and there were no significant differences in the induced reversion frequencies over this pH range in S. typhimurium.},
doi = {10.2172/6594384},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Dec 01 00:00:00 EST 1978},
month = {Fri Dec 01 00:00:00 EST 1978}
}

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