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Title: Prolonged survival of lung allografts in nonidentical beagles by treatment with lethal total-body irradiation, autologous bone marrow transplantation, and methotrexate. [Gamma radiation]

Abstract

Techniques are described for /sup 60/Co irradiation of beagles and transplantation of bone marrow and lungs. Eight pairs of animals that were treated with lethal irradiation, marrow transplantation, and methotrexate were alive after 68 to 245 days. Biopsies revealed normal transplanted lungs. Results indicated that the combination of treatments was significant since survival was markedly increased over various control series receiving lesser degrees of therapy or none. (HLW)

Authors:
;
Publication Date:
Research Org.:
Columbia Univ., Coopertown, NY
OSTI Identifier:
6585628
Resource Type:
Journal Article
Journal Name:
Transplantation; (United States)
Additional Journal Information:
Journal Volume: 26:3
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BONE MARROW; BIOLOGICAL EFFECTS; TRANSPLANTS; LUNGS; METHOTREXATE; BIOLOGICAL RADIATION EFFECTS; BEAGLES; GAMMA RADIATION; SURVIVAL TIME; ANIMALS; ANTIMETABOLITES; ANTIMITOTIC DRUGS; BODY; DOGS; DRUGS; ELECTROMAGNETIC RADIATION; HEMATOPOIETIC SYSTEM; IONIZING RADIATIONS; MAMMALS; ORGANS; RADIATION EFFECTS; RADIATIONS; RESPIRATORY SYSTEM; TISSUES; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals

Citation Formats

Blumenstock, D A, and Cannon, F D. Prolonged survival of lung allografts in nonidentical beagles by treatment with lethal total-body irradiation, autologous bone marrow transplantation, and methotrexate. [Gamma radiation]. United States: N. p., 1978. Web.
Blumenstock, D A, & Cannon, F D. Prolonged survival of lung allografts in nonidentical beagles by treatment with lethal total-body irradiation, autologous bone marrow transplantation, and methotrexate. [Gamma radiation]. United States.
Blumenstock, D A, and Cannon, F D. 1978. "Prolonged survival of lung allografts in nonidentical beagles by treatment with lethal total-body irradiation, autologous bone marrow transplantation, and methotrexate. [Gamma radiation]". United States.
@article{osti_6585628,
title = {Prolonged survival of lung allografts in nonidentical beagles by treatment with lethal total-body irradiation, autologous bone marrow transplantation, and methotrexate. [Gamma radiation]},
author = {Blumenstock, D A and Cannon, F D},
abstractNote = {Techniques are described for /sup 60/Co irradiation of beagles and transplantation of bone marrow and lungs. Eight pairs of animals that were treated with lethal irradiation, marrow transplantation, and methotrexate were alive after 68 to 245 days. Biopsies revealed normal transplanted lungs. Results indicated that the combination of treatments was significant since survival was markedly increased over various control series receiving lesser degrees of therapy or none. (HLW)},
doi = {},
url = {https://www.osti.gov/biblio/6585628}, journal = {Transplantation; (United States)},
number = ,
volume = 26:3,
place = {United States},
year = {Fri Sep 01 00:00:00 EDT 1978},
month = {Fri Sep 01 00:00:00 EDT 1978}
}