Oxygen at 2 atmospheres absolute pressure does not increase the radiation sensitivity of normal brain in rats
Cranial radiation was administered to CD Fisher rats at 1.0, 1.5 and 2.0 atmospheres oxygen pressure. Life span following radiation was recorded. Surviving animals were killed at 28 weeks and the brains were examined independently by two neuropathologists. Survival time was significantly less in animals receiving higher doses of radiation but showed no relationship to the oxygen pressure in the environment of the animal at the time radiation was administered. Microscopic examination of the brain did not reveal any differences in animals radiated in a normobaric or hyperbaric oxygen environment. It is concluded that hyperbaric oxygen does not sensitize the normal brain to the effects of ionizing radiation.
- Research Organization:
- Univ. of Mississippi School of Medicine, Jackson
- OSTI ID:
- 6578683
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 10:7
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
BIOLOGICAL RADIATION EFFECTS
HISTOLOGY
LIFE SPAN
OXYGEN
RADIOSENSITIVITY EFFECTS
NECROSIS
RATS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CENTRAL NERVOUS SYSTEM
ELEMENTS
MAMMALS
NERVOUS SYSTEM
NONMETALS
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RODENTS
VERTEBRATES
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)